|
| Status |
Public on Jan 23, 2018 |
| Title |
Molecular portraits of tumor mutational and micro-environmental sculpting by immune checkpoint blockade therapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Immune checkpoint blockade (ICB) has demonstrated significant promise for the treatment of advanced malignancies. Anti-CTLA4 and ant-PD1 therapy can activate the immune system and result in durable control in diseases such as melanoma and non-small cell lung cancer.
|
| |
|
| Overall design |
109 RNASeq samples (58 On-treatment and 51 Pre-treatment) from 65 patients
|
| |
|
| Contributor(s) |
Riaz N, Have JJ, Makarov V, Desrichard A, Chan TA |
| Citation(s) |
29033130 |
| |
| Submission date |
Dec 08, 2016 |
| Last update date |
May 15, 2019 |
| Contact name |
Vladimir Makarov |
| E-mail(s) |
makarov@ccf.org
|
| Organization name |
Cleveland Clinic
|
| Department |
LRI
|
| Lab |
CITI
|
| Street address |
9500 Euclid Ave
|
| City |
Cleveland |
| State/province |
OH |
| ZIP/Postal code |
44195 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
|
| Samples (109)
|
|
| Relations |
| BioProject |
PRJNA356761 |
| SRA |
SRP094781 |
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