|
Status |
Public on Jan 23, 2018 |
Title |
Molecular portraits of tumor mutational and micro-environmental sculpting by immune checkpoint blockade therapy |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
Immune checkpoint blockade (ICB) has demonstrated significant promise for the treatment of advanced malignancies. Anti-CTLA4 and ant-PD1 therapy can activate the immune system and result in durable control in diseases such as melanoma and non-small cell lung cancer.
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|
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Overall design |
109 RNASeq samples (58 On-treatment and 51 Pre-treatment) from 65 patients
|
|
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Contributor(s) |
Riaz N, Have JJ, Makarov V, Desrichard A, Chan TA |
Citation(s) |
29033130 |
|
Submission date |
Dec 08, 2016 |
Last update date |
May 15, 2019 |
Contact name |
Vladimir Makarov |
E-mail(s) |
makarov@ccf.org
|
Organization name |
Cleveland Clinic
|
Department |
LRI
|
Lab |
CITI
|
Street address |
9500 Euclid Ave
|
City |
Cleveland |
State/province |
OH |
ZIP/Postal code |
44195 |
Country |
USA |
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|
Platforms (1) |
GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
|
Samples (109)
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|
Relations |
BioProject |
PRJNA356761 |
SRA |
SRP094781 |