|
| Status |
Public on Jul 14, 2015 |
| Title |
Gene expression in zebrafish following knockdown of pitx2 or tbx5 |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by array
|
| Summary |
Key regulators of septum formation between the left and right ventricle in mammals, including the transcription factors TXB5 and PITX2, feature loss-of-function phenotypes that affect development of the two-chambered zebrafish heart, suggesting
uncharacterized primordial functions of these septation regulators prior to the evolution of any physical boundaries between heart chambers. Data is as published in Mosimann & Panakova et al (Nature Communications, 2015)
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| |
|
| Overall design |
Samples for tbx5a versus pitx2ab MO comparison were collected from three independent experiments of MO-injected siblings and uninjected wildtype controls at 56hpf by morphology.
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| |
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| Contributor(s) |
Zon L, Mosimann C |
| Citation(s) |
26697374, 26306682 |
| |
| Submission date |
Jul 10, 2015 |
| Last update date |
Nov 29, 2017 |
| Contact name |
Gabriel Musso |
| E-mail(s) |
gabe.musso@gmail.com
|
| Organization name |
Harvard Medical School
|
| Department |
Medicine
|
| Lab |
MacRae
|
| Street address |
75 Francis St, Thorn 1123
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16933 |
[ZebGene-1_0-st] Zebrafish Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (9)
|
|
| Relations |
| BioProject |
PRJNA289628 |
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