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| Status |
Public on Jun 16, 2015 |
| Title |
Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme [I] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to elucidate the role of DNA methylation in the DME gene regulation, global DNA methylation and mRNA expression profiles of human tissues and cell lines were examinde by HumanMethylation450 Bead Chip and SurePrint G3 Human Gene Expression 8×60K v2. We demonstrated DNA methylation landscape of the DME genes in human tissues. Although a fraction of DME genes can be regulated by their DNA methylation, the variable DNA methylation status probably affects drug metabolism and response.
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| Overall design |
Total RNA was isolated from 2 human tissues (liver and small intestine) and 3 human hepatoma cells that were treated with or without 5-aza-2’-deoxycytidine, and used for mRNA expression analysis.
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| Contributor(s) |
Habano W |
| Citation(s) |
26421064 |
| |
| Submission date |
Mar 26, 2015 |
| Last update date |
Apr 01, 2020 |
| Contact name |
Wataru Habano |
| Organization name |
Iwate Medical University
|
| Department |
Pharmacodynamics and Molecular Genetics
|
| Street address |
2-1-1 Nishitokuta
|
| City |
Yahaba-Cho, Shiwa-Gun |
| State/province |
Iwate |
| ZIP/Postal code |
028-3694 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE67485 |
Global DNA methylation landscape reveals roles of DNA methylation involved in the regulation of drug metabolizing enzyme |
|
| Relations |
| BioProject |
PRJNA279493 |
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