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| Status |
Public on Nov 22, 2014 |
| Title |
Identification of transcript dysregulation in patients with Autism Spectrum Disorders |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to unveil the molecular mechanisms at play during the development of autistic brains, we studied cells that are representative of the very early stages of ontogenesis, namely stem cells. We used nasal olfactory stem cells that are readily accessible and can be biopsied safely. We recruited a relatively homogeneous cohort of nine adults with severe autism and low to very low developmental disabilities, and included two more adults with either Asperger syndrome or high-functioning autism, to enlarge the spectrum. The cohort was then paired with 11 age- and gender-matched control individuals. Stem cells were purified, banked and used for a transcriptomic study.
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| Overall design |
Two-colors experiment. The cohort was then paired with 11 age- and gender-matched control individuals. Stem cells were purified, banked and used for a transcriptomic study. Validation by reverse transcription design.
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| Contributor(s) |
Féron F, Stephan D, Mesnage B, Lacassagne E, Devèze A, Loriod B, Rousseau S, Tardif C, Nivet E, Gepner B, Garcia M |
| Citation(s) |
26239292 |
| |
| Submission date |
Nov 20, 2014 |
| Last update date |
Mar 01, 2021 |
| Contact name |
Aurelie Bergon |
| E-mail(s) |
aurelie.bergon@inserm.fr
|
| Phone |
+33(0) 491 828 724
|
| Organization name |
TAGC INSERM U1090
|
| Street address |
parc scientifique de Luminy, case 928
|
| City |
MARSEILLE CEDEX 09 |
| ZIP/Postal code |
13 288 |
| Country |
France |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA268178 |
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