|
| Status |
Public on Jan 22, 2016 |
| Title |
Wild-type and Mecp2 -/y callosal projection neurons |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Mutations of the transcriptional regulator Mecp2 cause the X-linked autism spectrum disorder Rett syndrome (RTT), and Mecp2 has been implicated in several other neurodevelopmental disorders. To identify potential target genes regulated directly or indirectly by MeCP2, we performed comparative gene expression analysis via oligonucleotide microarrays on Mecp2-/y (Mecp2-null) and wild-type CPN purified via fluorescence-activated cell sorting (FACS).
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| |
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| Overall design |
Independent RNA samples were collected from three independent FACS purifications for both wild-type and Mecp2 -/y callosal projection neurons.
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| Contributor(s) |
Kishi N, MacDonald JL, Ye J, Molyneaux BJ, Azim E, Macklis JD |
| Citation(s) |
26821816 |
| |
| Submission date |
Aug 27, 2013 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Noriyuki Kishi |
| E-mail(s) |
noriyukik@nifty.com
|
| Organization name |
Keio Univ. School of Medicine
|
| Department |
Department of Physiology
|
| Lab |
Hideyuki Okano Lab
|
| Street address |
35 Shinanomachi
|
| City |
Shinjuku-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
160-8582 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
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| Relations |
| BioProject |
PRJNA217318 |
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