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| Status |
Public on Aug 07, 2013 |
| Title |
Changes in gene expression profiles of circulating B cells after influenza vaccination in healthy human subjects |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Daily sampling of peripheral blood from human subjects vaccinated for influenza was done immediately before vaccination and for 10 days after vaccination. In B cells, 90% of transcriptomic variation in subjects who received influenza vaccine within the previous three years was explained by a single temporal pattern unique to the individual. A common set of 742 genes was strongly correlated with the migration of differentiating plasma cell subtypes.
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| |
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| Overall design |
Five subjects, 11 time points per subject (pre-vaccination and daily for 10 days post-vaccination)
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| |
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| Contributor(s) |
Welle SL, Henn AD, Zand MS |
| Citation(s) |
23900141 |
| |
| Submission date |
Apr 03, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Stephen Welle |
| E-mail(s) |
swelle@rochester.rr.com
|
| Organization name |
University of Rochester
|
| Street address |
601 Elmwood Avenue
|
| City |
Rochester |
| State/province |
NY |
| ZIP/Postal code |
14642 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL10999 |
Illumina Genome Analyzer IIx (Homo sapiens) |
|
| Samples (55)
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| This SubSeries is part of SuperSeries: |
| GSE45764 |
Effect of influenza vaccination on PBMC and B cell gene expression profiles in healthy humans |
|
| Relations |
| BioProject |
PRJNA196147 |
| SRA |
SRP020491 |
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