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Series GSE44037 Query DataSets for GSE44037
Status Public on Feb 05, 2013
Title Expression data from airway epithelial cells from patients with asthma, rhinitis, and helathy controls
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The link between upper and lower airways in patients with both asthma and allergic rhinitis is still poorly understood. As the biological complexity of these disorders can be captured by gene expression profiling we hypothesized that the clinical expression of rhinitis and/or asthma is related to differential gene expression between upper and lower airways epithelium.
We used micro array to profile gene expression of primary nasal and bronchial epithelial cells from the same individuals and examining the impact of allergic rhinitis with and without concomitant allergic asthma on expression profiles.
 
Overall design 17 subjects were included in a cross-sectional study (6 allergic asthma and allergic rhinitis; 5 allergic rhinitis; 6 healthy controls). RNA was extracted from isolated and cultured epithelial cells from bronchial brushes and nasal biopsies, and analyzed by microarray (Affymetrix U133+ PM Genechip Array).
 
Contributor(s) Wagener AH, Luiten S, Zwinderman AH, van Drunen CM, Sterk PJ
Citation(s) 24282527
Submission date Feb 04, 2013
Last update date Apr 20, 2018
Contact name Ariane Wagener
E-mail(s) A.H.Wagener@amc.uva.nl
Organization name Academic Medical Center
Street address Meibergdreef 9
City Amsterdam
ZIP/Postal code 1015 AZ
Country Netherlands
 
Platforms (1)
GPL13158 [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate
Samples (34)
GSM1077128 10_B05_bronchial_epithelium_rhinitis_subject
GSM1077129 13_F09_nasal_epithelium_healthy_subject
GSM1077130 16_D09_bronchial_epithelium_rhinitis_subject
Relations
BioProject PRJNA188406

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE44037_RAW.tar 71.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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