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| Status |
Public on Aug 31, 2013 |
| Title |
Gene expression profiling of five diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4, DHL6, LY7, HBL1 and U2932, treated with the SYK inhibitor, R406 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The five DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent phosphorylation of BCR signaling components such as BLNK.
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| |
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| Overall design |
RNA samples from five DLBCL cell lines treated with R406 or vehicle (DMSO) alone for 0, 6, or 24 hours were profiled in triplicate on Affymetrix HT_HG-U133plust2 chips.
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| Contributor(s) |
Monti S, Chen L, Margaret S |
| Citation(s) |
23764004 |
| |
| Submission date |
Jan 15, 2013 |
| Last update date |
May 15, 2014 |
| Contact name |
Stefano Monti |
| E-mail(s) |
smonti@bu.edu
|
| Organization name |
Boston University
|
| Department |
Medicine
|
| Lab |
Computational Biomedicine
|
| Street address |
72 East Concord st. E-613B
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02118 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL16268 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray ENSG Version 16] |
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| Samples (75)
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| Relations |
| BioProject |
PRJNA186620 |
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