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| Status |
Public on Nov 16, 2012 |
| Title |
Profiling of differentially expressed genes in sheep T lymphocytes response to Haemonchus contortus infection |
| Organism |
Ovis aries |
| Experiment type |
Expression profiling by array
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| Summary |
Once Haemonchus contortus infects sheep it receives a series of host attacks, especially those relating to the infected animal’s T lymphocytes immune response. To obtain a systematic genome-wide profiling of the T lymphocyte genes involved, microarrays were used to compare gene expression between 0 days post infection (dpi), 3-5 dpi, 25-30 dpi and 60dpi in infected sheep. In this 853, 242 and 42 differentially expressed genes were acquired in the 3d vs. 0d comparison, the 30d vs. 0d comparison and the 60d vs. 0d comparison, respectively. Gene Ontology and pathway analysis indicated that modulated genes including SUGT1, FCER1G, CD23, IL-13 and galectin-14, were mostly associated with cellular homeostasis maintaining and immune response.
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| Overall design |
Haemonchus contortus infection induced gene expression in sheep T lymphocytes was measured at 0, 3, 30 and 60 days post infection. Four time-series experiments were performed at each sheep (2#, 3# and 5#).
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| Contributor(s) |
Yang Y, Du A |
| Citation missing |
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| |
| Submission date |
Nov 15, 2012 |
| Last update date |
Nov 17, 2012 |
| Contact name |
Aifang Du |
| E-mail(s) |
afdu@zju.edu.cn
|
| Phone |
+86 571 8898 2583
|
| Fax |
+86 571 8898 2583
|
| Organization name |
Institute of Preventive Veterinary Medicine
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| Department |
College of Animal Sciences, Zhejiang University
|
| Street address |
Yuhangtang Road 866
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310058 |
| Country |
China |
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| Platforms (1) |
| GPL16283 |
Agilent-028803 Custom Whole Sheep Genome Oligo Microarray |
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| Samples (13)
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| Relations |
| BioProject |
PRJNA181000 |
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