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| Status |
Public on Jan 08, 2018 |
| Title |
IER5 is a novel Notch target gene that contributes to the effects of Notch on breast cancer stem / progenitor cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The Notch signalling pathway has been implicated in the development and progression of numerous malignancies, including breast cancer. In breast cancer, the transcriptional programs elicited by Notch activation and the target genes responsible for mediating the downstream effects of the pathway remain poorly understood. Here, we characterise the immediate cellular consequences of Notch activation in breast cancer cells and identify a panel of direct Notch targets with potential relevance in the disease. One key direct transcriptional target of Notch in this context is IER5. Functionally, IER5 activation in breast cancer contributes to the effects of Notch signalling on the self-renewal and proliferative potential of breast cancer stem and progenitor cells. High levels of IER5 mRNA may be an important biomarker indicative of Notch activation in the disease.
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| Overall design |
Four treatment conditions were compared in triplicate: no treatment (control), EDTA, γ-secretase inhibition (gsi) and the combination of EDTA and GSI (edtagsi)
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| Contributor(s) |
Dawson S, Menon S |
| Citation missing |
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| Submission date |
Jun 29, 2011 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Suraj Menon |
| E-mail(s) |
suraj.menon@cruk.cam.ac.uk
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| Organization name |
Cambridge Research Institute, Cancer Research UK
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| Street address |
Li Ka Shing Center, Robinson Way
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| City |
Cambridge |
| ZIP/Postal code |
CB2 0RE |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA143591 |
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