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| Status |
Public on Oct 28, 2011 |
| Title |
Potential Prognostic Biomarkers for Bone Metastasis from Hepatocellular Carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
RNA was extracted from 48 pairs of intratumoral and peritumoral formalin-fixed, paraffin-embedded (FFPE) tissue from hepatocellular carcinoma (HCC) patients with and without bone metastases (BM). The Human Cancer Panel DASL Assay containing 502 cancer-related genes was used to identify novel BM-associated genes. A cDNA-mediated annealing, selection, extension, and ligation assay was performed with an array of 502 known cancer-related genes to identify differentially expressed genes in 96 RNA samples.
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| Overall design |
Total RNA was purified from the tissue specimens using the High Pure RNA Paraffin Kit according to the manufacturer’s protocol. DASL experiments were performed to identify genes that were differentially expressed between the BM and NBM groups of matched intratumoral and peritumoral tissues by using A cDNA-mediated annealing, selection, extension, and ligation assay.
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| Contributor(s) |
Xiang Z, Zeng Z, Tang Z, Fan J, He J, Zeng H, Zhu X |
| Citation(s) |
21665914 |
| |
| Submission date |
Mar 02, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
Zuolin Xiang |
| E-mail(s) |
xzl815@sohu.com
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| Organization name |
Zhongshan Hospital, Fudan University
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| Street address |
136 Yi Xue Yuan Road
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| City |
Shanghai |
| ZIP/Postal code |
200032 |
| Country |
China |
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| Platforms (1) |
| GPL5858 |
DASL Human Cancer Panel by Gene |
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| Samples (96)
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| GSM684748 |
peritumoral HCC, bone metastasis, patient 1 |
| GSM684749 |
intratumoral HCC, bone metastasis, patient 1 |
| GSM684750 |
peritumoral HCC, bone metastasis, patient 2 |
| GSM684751 |
intratumoral HCC, bone metastasis, patient 2 |
| GSM684752 |
peritumoral HCC, bone metastasis, patient 3 |
| GSM684753 |
intratumoral HCC, bone metastasis, patient 3 |
| GSM684754 |
peritumoral HCC, bone metastasis, patient 4 |
| GSM684755 |
intratumoral HCC, bone metastasis, patient 4 |
| GSM684756 |
peritumoral HCC, bone metastasis, patient 5 |
| GSM684757 |
intratumoral HCC, bone metastasis, patient 5 |
| GSM684758 |
peritumoral HCC, bone metastasis, patient 6 |
| GSM684759 |
intratumoral HCC, bone metastasis, patient 6 |
| GSM684760 |
peritumoral HCC, bone metastasis, patient 7 |
| GSM684761 |
intratumoral HCC, bone metastasis, patient 7 |
| GSM684762 |
peritumoral HCC, bone metastasis, patient 8 |
| GSM684763 |
intratumoral HCC, bone metastasis, patient 8 |
| GSM684764 |
peritumoral HCC, bone metastasis, patient 9 |
| GSM684765 |
intratumoral HCC, bone metastasis, patient 9 |
| GSM684766 |
peritumoral HCC, bone metastasis, patient 10 |
| GSM684767 |
intratumoral HCC, bone metastasis, patient 10 |
| GSM684768 |
peritumoral HCC, bone metastasis, patient 11 |
| GSM684769 |
intratumoral HCC, bone metastasis, patient 11 |
| GSM684770 |
peritumoral HCC, bone metastasis, patient 12 |
| GSM684771 |
intratumoral HCC, bone metastasis, patient 12 |
| GSM684772 |
peritumoral HCC, bone metastasis, patient 13 |
| GSM684773 |
intratumoral HCC, bone metastasis, patient 13 |
| GSM684774 |
peritumoral HCC, bone metastasis, patient 14 |
| GSM684775 |
intratumoral HCC, bone metastasis, patient 14 |
| GSM684776 |
peritumoral HCC, bone metastasis, patient 15 |
| GSM684777 |
intratumoral HCC, bone metastasis, patient 15 |
| GSM684778 |
peritumoral HCC, bone metastasis, patient 16 |
| GSM684779 |
intratumoral HCC, bone metastasis, patient 16 |
| GSM684780 |
peritumoral HCC, bone metastasis, patient 17 |
| GSM684781 |
intratumoral HCC, bone metastasis, patient 17 |
| GSM684782 |
peritumoral HCC, bone metastasis, patient 18 |
| GSM684783 |
intratumoral HCC, bone metastasis, patient 18 |
| GSM684784 |
peritumoral HCC, bone metastasis, patient 19 |
| GSM684785 |
intratumoral HCC, bone metastasis, patient 19 |
| GSM684786 |
peritumoral HCC, bone metastasis, patient 20 |
| GSM684787 |
intratumoral HCC, bone metastasis, patient 20 |
| GSM684788 |
peritumoral HCC, bone metastasis, patient 21 |
| GSM684789 |
intratumoral HCC, bone metastasis, patient 21 |
| GSM684790 |
peritumoral HCC, bone metastasis, patient 22 |
| GSM684791 |
intratumoral HCC, bone metastasis, patient 22 |
| GSM684792 |
peritumoral HCC, bone metastasis, patient 23 |
| GSM684793 |
intratumoral HCC, bone metastasis, patient 23 |
| GSM684794 |
peritumoral HCC, bone metastasis, patient 24 |
| GSM684795 |
intratumoral HCC, bone metastasis, patient 24 |
| GSM684796 |
peritumoral HCC, no bone metastasis, patient 25 |
| GSM684797 |
intratumoral HCC, no bone metastasis, patient 25 |
| GSM684798 |
peritumoral HCC, no bone metastasis, patient 26 |
| GSM684799 |
intratumoral HCC, no bone metastasis, patient 26 |
| GSM684800 |
peritumoral HCC, no bone metastasis, patient 27 |
| GSM684801 |
intratumoral HCC, no bone metastasis, patient 27 |
| GSM684802 |
peritumoral HCC, no bone metastasis, patient 28 |
| GSM684803 |
intratumoral HCC, no bone metastasis, patient 28 |
| GSM684804 |
peritumoral HCC, no bone metastasis, patient 29 |
| GSM684805 |
intratumoral HCC, no bone metastasis, patient 29 |
| GSM684806 |
peritumoral HCC, no bone metastasis, patient 30 |
| GSM684807 |
intratumoral HCC, no bone metastasis, patient 30 |
| GSM684808 |
peritumoral HCC, no bone metastasis, patient 31 |
| GSM684809 |
intratumoral HCC, no bone metastasis, patient 31 |
| GSM684810 |
peritumoral HCC, no bone metastasis, patient 32 |
| GSM684811 |
intratumoral HCC, no bone metastasis, patient 32 |
| GSM684812 |
peritumoral HCC, no bone metastasis, patient 33 |
| GSM684813 |
intratumoral HCC, no bone metastasis, patient 33 |
| GSM684814 |
peritumoral HCC, no bone metastasis, patient 34 |
| GSM684815 |
intratumoral HCC, no bone metastasis, patient 34 |
| GSM684816 |
peritumoral HCC, no bone metastasis, patient 35 |
| GSM684817 |
intratumoral HCC, no bone metastasis, patient 35 |
| GSM684818 |
peritumoral HCC, no bone metastasis, patient 36 |
| GSM684819 |
intratumoral HCC, no bone metastasis, patient 36 |
| GSM684820 |
peritumoral HCC, no bone metastasis, patient 37 |
| GSM684821 |
intratumoral HCC, no bone metastasis, patient 37 |
| GSM684822 |
peritumoral HCC, no bone metastasis, patient 38 |
| GSM684823 |
intratumoral HCC, no bone metastasis, patient 38 |
| GSM684824 |
peritumoral HCC, no bone metastasis, patient 39 |
| GSM684825 |
intratumoral HCC, no bone metastasis, patient 39 |
| GSM684826 |
peritumoral HCC, no bone metastasis, patient 40 |
| GSM684827 |
intratumoral HCC, no bone metastasis, patient 40 |
| GSM684828 |
peritumoral HCC, no bone metastasis, patient 41 |
| GSM684829 |
intratumoral HCC, no bone metastasis, patient 41 |
| GSM684830 |
peritumoral HCC, no bone metastasis, patient 42 |
| GSM684831 |
intratumoral HCC, no bone metastasis, patient 42 |
| GSM684832 |
peritumoral HCC, no bone metastasis, patient 43 |
| GSM684833 |
intratumoral HCC, no bone metastasis, patient 43 |
| GSM684834 |
peritumoral HCC, no bone metastasis, patient 44 |
| GSM684835 |
intratumoral HCC, no bone metastasis, patient 44 |
| GSM684836 |
peritumoral HCC, no bone metastasis, patient 45 |
| GSM684837 |
intratumoral HCC, no bone metastasis, patient 45 |
| GSM684838 |
peritumoral HCC, no bone metastasis, patient 46 |
| GSM684839 |
intratumoral HCC, no bone metastasis, patient 46 |
| GSM684840 |
peritumoral HCC, no bone metastasis, patient 47 |
| GSM684841 |
intratumoral HCC, no bone metastasis, patient 47 |
| GSM684842 |
peritumoral HCC, no bone metastasis, patient 48 |
| GSM684843 |
intratumoral HCC, no bone metastasis, patient 48 |
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| Relations |
| BioProject |
PRJNA138235 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE27635_differential.txt.gz |
115.4 Kb |
(ftp)(http) |
TXT |
| GSE27635_non-normalized.txt.gz |
838.1 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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