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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 18, 2023 |
| Title |
Sex differences in cardiac aging in mice and development of a female murine model of hypertensive disease in the elderly |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
C57Bl6/J male and female mice were gonadectomized or not at the age of 12 months and then euthanized 12 months later at the age of 24 months. Half of the females received for 28 days an angiotensin II (AngII; 1.5 mg/kg/day) continuous infusion starting at the age of 23 months. The mice were provided with a running wheel during the 12 months after gonadectomy with the exception of the last month before euthanasia.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for mouse left ventricle samples of both sexes (M or F) from various groups (Controls (Ctr) or Gonadectomised (Gx)) at the age of 24 months. Half of the females were treated for with Angiotensin II(AngII) 4 weeks before euthanasia .
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| Contributor(s) |
Couet J, Walsh-Wilkinson E, Morin-Grandmont A |
| Citation(s) |
38363584, 38799057 |
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| Submission date |
Dec 12, 2023 |
| Last update date |
Jun 12, 2024 |
| Contact name |
Jacques Couet |
| E-mail(s) |
jacques.couet@med.ulaval.ca
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| Phone |
1-418-656-4760
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| Organization name |
Université Laval
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| Department |
Medicine
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| Lab |
CRIUCPQ
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| Street address |
2725 Chemin Sainte-Foy
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| City |
Quebec |
| State/province |
QC |
| ZIP/Postal code |
G1V 4G5 |
| Country |
Canada |
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| Platforms (1) |
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| Samples (24)
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| GSM7971979 |
Male, Control (Sample 49) |
| GSM7971980 |
Male, Gx (Sample 34) |
| GSM7971981 |
Male, Gx (Sample 35) |
| GSM7971982 |
Male, Gx (Sample 36) |
| GSM7971983 |
Male, Gx (Sample 50) |
| GSM7971984 |
Female, Control (Sample 37) |
| GSM7971985 |
Female, Control (Sample 38) |
| GSM7971986 |
Female, Control (Sample 39) |
| GSM7971987 |
Female, Control (Sample 51) |
| GSM7971988 |
Female, Gx (Sample 43) |
| GSM7971989 |
Female, Gx (Sample 44) |
| GSM7971990 |
Female, Gx (Sample 45) |
| GSM7971991 |
Female, Gx (Sample 53) |
| GSM7971992 |
Female, Control, AngII (Sample 40) |
| GSM7971993 |
Female, Control, AngII (Sample 41) |
| GSM7971994 |
Female, Control, AngII (Sample 42) |
| GSM7971995 |
Female, Control, AngII (Sample 52) |
| GSM7971996 |
Female, Gx, AngII (Sample 46) |
| GSM7971997 |
Female, Gx, AngII (Sample 47) |
| GSM7971998 |
Female, Gx, AngII (Sample 48) |
| GSM7971999 |
Female, Gx, AngII (Sample 54) |
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| Relations |
| BioProject |
PRJNA1051667 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE250052_Processed_data_submission_GEO.xlsx |
6.4 Mb |
(ftp)(http) |
XLSX |
SRA Run Selector |
| Raw data are available in SRA |
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