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| Status |
Public on Mar 19, 2024 |
| Title |
Expression data from T-cell Acute Lymphoblastic Leukemia (T-ALL) patient-derived xenograft treated with anti-CD3 mAb |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
T-cell acute lymphoblastic leukemia is a hematological malignancy treated by chemotherapy, with a poor prognosis. We have demonstrated that activation of the T cell receptor (TCR) by anti-CD3 antibodies has a potent anti-leukemic effect in patient-derived xenograft models (PDX) of T-ALL. Therefore, with this experiment, we aim to identify the molecular mechanisms underlying the anti-leukemic properties of the OKT3 anti-CD3 mAb in T-ALL PDX.
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| Overall design |
T-ALL PDX were treated with the isotype control antibody IgG2a or OKT3 mAb. After 6 hours of treatment, T-ALL cells were extracted and isolated from mouse cells by FACS sorting (hCD45+, hCD7+) for RNA collection. RNA-sequencing data were used to compare gene expression profiles upon OKT3 mAb treatment.
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| Contributor(s) |
Avila Avila A, Zaniboni B, Druillennec S, Ghysdael J, Tran Quang C |
| Citation(s) |
38437728 |
| |
| Submission date |
Aug 07, 2023 |
| Last update date |
Mar 19, 2024 |
| Contact name |
Christine Tran Quang |
| E-mail(s) |
christine.tran-quang@curie.fr
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| Organization name |
Institut Curie
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| Street address |
Bat 110 centre universitaire
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| City |
Orsay |
| ZIP/Postal code |
91405 |
| Country |
France |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA1003109 |
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