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| Status |
Public on Sep 10, 2010 |
| Title |
Effect of imatinib on philadelphia chromosome positive acute lymphoblastic leukemia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The Philadelphia chromosome (Ph) encodes the oncogenic BCR-ABL1 tyrosine kinase, which defines a subset of acute lymphoblastic leukemia (ALL) with a particularly unfavorable prognosis. In this study, the tyrosine kinase inhibitor imatinib was used for pharmacological inhibition of BCR-ABL1. Gene expression profiles of Ph+ ALL cell lines were analyzed in response to imatinib treatment.
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| Overall design |
Four Ph+ ALL cell lines (BV-173, NALM-1, SUP-B15, and TOM1) were either treated with 10µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571.
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| Contributor(s) |
Duy C, Hurtz C, Cerchietti L, Klemm L, Swaminathan S, Shojaee S, Ci W, Geng H, Braig M, Hofmann W, Koeffler PH, Yu JJ, Nahar R, Kweon S, Hennighausen L, Herzog S, Jumaa H, Park E, Kim Y, Groffen J, Heisterkamp N, Ye HB, Melnick AM, Müschen M |
| Citation(s) |
21593872 |
| Submission date |
Aug 22, 2010 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Markus Müschen |
| E-mail(s) |
mmuschen@chla.usc.edu
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| Phone |
+ 1 323 361 5592
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| Fax |
+1 323 361 1516
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| URL |
http://www.lymphocytes.de/
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| Organization name |
University of Southern California
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| Department |
Childrens Hospital Los Angeles
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| Lab |
Müschen Lab
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| Street address |
4650 Sunset Blvd
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA130771 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE23743_RAW.tar |
14.6 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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