|
| Status |
Public on Jul 28, 2022 |
| Title |
Expression data from Hela cells treated with IHSF115, an inhibitor of HSF1. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
IHSF115 induces a transcriptomic response that resembles but is not identical with a typical heat stress response.
The data suggest that mRNAs of a number of genes, most notably including histone genes, were stabilized in IHSF115-exposed cells. For the remaining genes, exposure of cells to IHSF115 apparently increased their rates of transcription.
|
| |
|
| Overall design |
Transcriptomic changes in cells exposed to iHSF1 were analyzed in cells exposed for 6h to vehicle (DMSO) or IHSF, by triplicate. Transcript stabilization was analyzed in cells treated for 10min with DMSO or IHSF115 and then exposed fpor 1h to actinomycin D, by duplicate.
|
| |
|
| Contributor(s) |
Vilaboa N, Voellmy R |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 25, 2022 |
| Last update date |
Jul 30, 2022 |
| Contact name |
Nuria Vilaboa |
| E-mail(s) |
nuria.vilaboa@salud.madrid.org
|
| Phone |
34 658386329
|
| Organization name |
Fundación para la Investigación Hospital La Paz, G83727057
|
| Street address |
Edificio IdiPAZ segunda planta, Hospital Universitario La Paz, Paseo de la Castellana 261
|
| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28046 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL16686 |
[HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version] |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA862113 |
Less...
More...