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| Status |
Public on May 03, 2023 |
| Title |
DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Affymetrix] |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities including DNA methylation and tri-methylation at histone H3Lys27 (H3K27me3) contribute to malignant transformation of ATL. Hence, we investigate the combined effect of DNA demethylating agents and enhancer of zeste homolog 2 (EZH2), which catalyze H3K27me3, inhibitors in ATL. Gene expression microarray analyses revealed that the combination changes gene expressions stronger than the single treatment.
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| Overall design |
To investigate the combined effect of a DNA demethylating agent (OR21) and an EZH2 inhibitor (EPZ-6438), comparing the gene expressions between OR21 and/or EPZ-6438 treated cells and untreated cells.
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| Contributor(s) |
Kurahashi Y, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Yamashita S, Hattori N, Nakamura H, Kawaguchi A, Ushijima T, Sueoka E, Kimura S |
| Citation(s) |
36516085 |
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| Submission date |
Nov 26, 2021 |
| Last update date |
May 04, 2023 |
| Contact name |
yuki kurahashi |
| E-mail(s) |
kurahashiyuuki.ohara@gmail.com
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| Organization name |
saga university
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| Street address |
nabeshima 5-1-1
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| City |
saga |
| State/province |
saga |
| ZIP/Postal code |
8498501 |
| Country |
Japan |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE189604 |
DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia |
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| Relations |
| BioProject |
PRJNA783864 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE189603_RAW.tar |
10.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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