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| Status |
Public on Mar 13, 2021 |
| Title |
Inflammatory gene expression profiling in peripheral blood from patients with Alzheimer’s disease reveals key pathways and hub genes with potential diagnostic utility |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Late-onset Alzheimer disease (LOAD) is the most common neurodegenerative disorder worldwide. Recent studies have shown that differential expression in genes (DEG) related to inflammatory response may result associated with disease onset and progression. This study aimed to explore the molecular pathogenesis of LOAD-related inflammation through next-generation sequencing, to assess RNA expression profiles in Alzheimer's disease patients and healthy controls.
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| Overall design |
RNA was isolated from whole blood from 5 LOAD cases and 10 controls (all female. Mean age 76.3±3.5). The amplicon sequencing approach using 20812 probes sets specific to human mRNA was applied to assess gene expression profiles, and functional annotation was performed.
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| Contributor(s) |
Cardona-Londoño KY, Medina-Salcedo JM, Orrego-Cardozo M, Restrepo de Mejía F, Elcoroaristizabal Martín X, Naranjo-Galvis CA |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Mar 12, 2021 |
| Last update date |
Mar 13, 2021 |
| Contact name |
Antonio Adamo |
| E-mail(s) |
antonio.adamo@kaust.edu.sa
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| Organization name |
King Abdullah University of Science and Technology
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| Department |
iological, Environmental Sciences and Engineering
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| Lab |
Stem cells and diseases laboratory
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| Street address |
Thuwal 23955-6900 KAUST
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| City |
Thuwal |
| State/province |
Makkah |
| ZIP/Postal code |
23955 |
| Country |
Saudi Arabia |
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| Platforms (1) |
| GPL17303 |
Ion Torrent Proton (Homo sapiens) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA714081 |
| SRA |
SRP310421 |
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