|
| Status |
Public on Aug 04, 2020 |
| Title |
Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity [zebrafish] |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: To explore the mechanism of how Tan I inhibits malignant hematopoiesis at the gene expression level
Methods: 72 hpf Tg(c-mybhyper: GFP) zebrafish embryos treated with DMSO or Tan I 60 μM were collected for RNA sequencing
Results: We found that 1882 genes were differentially expressed between DMSO and Tan I treatment in c-mybhyper fish embryos (p value <=0.05, |log2 fold change| >= 0.25)
Conclusions: We identified MMP9 and ABCG2 as two possible downstream genes of Tan I’s effects on EZH2
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| |
|
| Overall design |
72 hpf Tg(c-mybhyper: GFP) zebrafish embryos treated with DMSO or Tan I 60 μM
|
| |
|
| Contributor(s) |
Cheng T, Huang Y, Yu S |
| Citation(s) |
34093860 |
| |
| Submission date |
Aug 03, 2020 |
| Last update date |
Jun 09, 2021 |
| Contact name |
Tao cheng |
| E-mail(s) |
11818118@zju.edu.cn
|
| Phone |
0571-88208276
|
| Organization name |
Zhejiang University
|
| Department |
Institute of genetics
|
| Street address |
886 Yuhangtang Road
|
| City |
Hang Zhou |
| State/province |
Zhe Jiang |
| ZIP/Postal code |
310000 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24995 |
Illumina NovaSeq 6000 (Danio rerio) |
|
| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE155574 |
Tanshinone I inhibit normal and malignant hematopoiesis by repressing EZH2 activity |
|
| Relations |
| BioProject |
PRJNA650379 |
| SRA |
SRP275594 |
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