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Status |
Public on Aug 20, 2020 |
Title |
Cardiac-tbx20 overexpression enhances heart regeneration by promoting cardiomyocytes dedifferentiation and endocardial activation |
Organism |
Danio rerio |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
The goal of this study is to understand the function of cardiac tbx20 during heart regeneration. By high-throughput sequencing, molecular variations of tbx20-cardiac specific inducing heart in response to heart injury compared with control hearts were demonstrated. We collected the injured heart apex tissue at 7 days post injury and sequenced the transcriptome.
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Overall design |
RNA was extracted from ventricular apical portions at 7 days post injury from control hearts and tbx20-cardiac-specific inducing hearts. Tissue from 6-8 zebrafish were collected in each control group or cardiac-tbx20-overexpressing group, three replications were carried out.
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Contributor(s) |
Fang Y, Lai KS, Tao W, Zhong TP |
Citation(s) |
32850848 |
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https://doi.org/10.3389/fcell.2020.00738
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Submission date |
Feb 06, 2020 |
Last update date |
Aug 31, 2020 |
Contact name |
Tao Peter Zhong |
E-mail(s) |
taozhong@fudan.edu.cn, tzhong@bio.ecnu.edu.cn
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Organization name |
Fudan University
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Department |
School of Life Sciences
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Lab |
State Key Laboratory of Genetic Engineering
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Street address |
No.2005, Songhu Road
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City |
Shanghai |
State/province |
China |
ZIP/Postal code |
200438 |
Country |
China |
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Platforms (1) |
GPL14875 |
Illumina HiSeq 2000 (Danio rerio) |
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Samples (6)
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Relations |
BioProject |
PRJNA605096 |
SRA |
SRP247485 |