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| Status |
Public on Jan 09, 2009 |
| Title |
Comparison of stable human Treg and Th clones by transcriptional profiling - experiment I |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The aim of this work was to identify functional features that are specific of human Treg cells, through the identification of genes that are differentially expressed: 1/ in activated Treg clones versus activated Thelper clones; 2/ in Th clones activated in the presence versus the absence of TGFb; 3/ in suppressed Th clones, i.e. Th clones activated in the presence of Treg clones, versus controls.
Keywords: TCR activation
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| Overall design |
Two to four million cells of human T cell clones were collected at rest (time point = 0) or after activation with coated anti-CD3 and soluble anti-CD28 antibodies (time points = 6, 24 or 41hrs). RNA was extracted for hybridization on Affymetrix microarrays.
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| |
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| Contributor(s) |
Lucas S, Stockis J |
| Citation(s) |
19224638 |
| |
| Submission date |
Jan 08, 2009 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Sophie Lucas |
| E-mail(s) |
Sophie.Lucas@uclouvain.be
|
| Phone |
+32 2 764 7558
|
| Organization name |
de Duve Institute
|
| Street address |
avenue Hippocrate 74
|
| City |
Brussels |
| ZIP/Postal code |
1200 |
| Country |
Belgium |
| |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA111445 |
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