|
| Status |
Public on Apr 02, 2019 |
| Title |
GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The transcription factor IRF5 is essential for immune defense against pathogens. Here, the authors show that the microtubule-associated factor GEF-H1 plays a critical role in host defense against Listeria monocytogenes in macrophages via activation of the IRF5 kinase IKKe
|
| |
|
| Overall design |
Examination of MDP stimulated BMDM from WT, Arhgef2 and Irf5 KO mice
|
| |
|
| Contributor(s) |
Reinecker H |
| Citation(s) |
30902986 |
| |
| Submission date |
Feb 19, 2019 |
| Last update date |
Apr 02, 2019 |
| Contact name |
Hans-Christian Reinecker |
| E-mail(s) |
Hans-Christian.Reinecker@UTSouthwestern.edu
|
| Phone |
6173311574
|
| Organization name |
University of Texas Southwestern Medical Center
|
| Department |
Medicine
|
| Lab |
Reinecker Lab
|
| Street address |
J5.136, 5959 Harry Hines Boulevard
|
| City |
Dallas |
| State/province |
Texas |
| ZIP/Postal code |
75235-6472 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA523187 |
| SRA |
SRP186268 |
Less...
More...