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| Status |
Public on Dec 31, 2008 |
| Title |
Global effects of 2-methoxyestradiol on smooth muscle cell hyperproliferation and vascular remodeling in atherosclerosis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We used microarrays to detail transcriptional changes in cultured human smooth muscle cells in response to acute and chronic 2-methoxyestradiol treatment
2-ME, an endogenous metabolite. of estradiol, not only exerts cytotoxic effects on cancer cells but it also protects against multiple proliferative disorders, including atherosclerosis and injury-induced intimal thickening
Keywords: treatment vs. control
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| Overall design |
Human aortic smooth muscle cells cultures with/without 2-methoxyestradiol (acute/chronic treatment)
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| Contributor(s) |
Zaugg M, Lucchinetti E, Dubey R, Barchiesi-Bozzolo F |
| Citation(s) |
26487003 |
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| Submission date |
Jul 28, 2008 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Michael Zaugg |
| E-mail(s) |
michael.zaugg@usz.ch
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| Phone |
+41-1-255 11 11
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| Organization name |
Anesthesiology, University Hospital Zurich
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| Department |
Anesthesiology
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| Lab |
Perioperative Cardioprotection Research Group
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| Street address |
Raemistrasse 100
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| City |
Zurich |
| ZIP/Postal code |
8091 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| GSM307999 |
Control 4h culture, biological rep1 |
| GSM308000 |
Control 4h culture, biological rep2 |
| GSM308001 |
Control 4h culture, biological rep3 |
| GSM308002 |
ME-treated 4h culture, biological rep1 |
| GSM308003 |
ME-treated 4h culture, biological rep2 |
| GSM308004 |
ME-treated 4h culture, biological rep3 |
| GSM308005 |
Control 30 h culture, biological rep1 |
| GSM308006 |
Control 30 h culture, biological rep2 |
| GSM308007 |
Control 30 h culture, biological rep3 |
| GSM308008 |
ME-treated 30 h culture, biological rep2 |
| GSM308009 |
ME-treated 30 h culture, biological rep3 |
| GSM308010 |
ME-treated 30 h culture, biological rep4 |
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| Relations |
| BioProject |
PRJNA113643 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE12261_RAW.tar |
93.1 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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