CDX2 caudal type homeobox 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CDX2provided by VGNC
Official Full Name: caudal type homeobox 2provided by VGNC
Primary source: VGNC:VGNC:86527
See related: Ensembl:ENSSSCG00000009317
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: CDX-2
Expression: Restricted expression toward ovary (RPKM 5.8) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	11	NC_010453.5 (5339727..5346081, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	11	NC_010453.4 (5113685..5120021)

Chromosome 11 - NC_010453.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that SLC7A7 is a CDX2 target gene, and that CDX2 binds directly to the SLC7A7 promoter.
Title: CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells.
these results provide further insight into the functional diversity of CDX2 in early mammalian embryos.
Title: CDX2 is essential for cell proliferation and polarity in porcine blastocysts.
showed novel molecular regulation of CDX2 on Oct4, and provided important clues for clarifying the mechanism of interaction between CDX2 and Oct4 in embryo of mammals other than mouse
Title: Cdx2 represses Oct4 function via inducing its proteasome-dependent degradation in early porcine embryos.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in embryo development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: homeobox protein CDX-2

Names: caudal type homeobox transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.