id2.L inhibitor of DNA binding 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: id2.L
Official Full Name: inhibitor of DNA binding 2 L homeolog
Primary source: Xenbase:XB-GENE-481302
Locus tag: XELAEV_18028022mg
See related: AllianceGenome:Xenbase:XB-GENE-481302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: id2; XId2; id2-A
Summary: Predicted to enable bHLH transcription factor binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 5L

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (148169136..148195936)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (137094336..137097171)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the presence of neural crest is required for normal Id2 expression in Xenopus heart development
Title: Cardiac neural crest ablation alters Id2 gene expression in the developing heart.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within endodermal digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myotube cell development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron fate commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2-A

Names: Inhibitor of DNA binding 2-A; inhibitor of DNA binding 2, HLH protein L homeolog; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein L homeolog; inhibitor of differentiation 2-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.