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mespa.L mesoderm posterior homolog A L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397972, updated on 4-Nov-2024

Summary

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Official Symbol
mespa.L
Official Full Name
mesoderm posterior homolog A L homeolog
Primary source
Xenbase:XB-GENE-920837
Locus tag
XELAEV_18018344mg
See related
EnsemblRapid:ENSXLAG00005024509 AllianceGenome:Xenbase:XB-GENE-920837
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hen2; thy2; MESPB; mespa; thyl2; mespa-a; mespa-b; mespa.S; thylacine2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Acts upstream of or within somitomeric trunk muscle development. Predicted to be located in nucleus. Is expressed in musculoskeletal system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mespa.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
2
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (114829028..114831404)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (99394204..99396580)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene mesoderm posterior homolog B L homeolog Neighboring gene mesoderm posterior bHLH transcription factor 2 L homeolog Neighboring gene gonadotropin releasing hormone receptor 2 L homeolog Neighboring gene WD repeat domain 93 L homeolog Neighboring gene transfer RNA aspartic acid (anticodon GUC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Thylacine 1 is expressed segmentally within the paraxial mesoderm of the Xenopus embryo and interacts with the Notch pathway. Sparrow DB, et al. Development, 1998 Jun. PMID 9570769
  2. Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. Moreno TA, et al. Dev Biol, 2008 Mar 15. PMID 18261720, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within heart morphogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesoderm formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somite rostral/caudal axis specification IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitomeric trunk muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mesoderm posterior homolog A L homeolog
Names
mesoderm posterior homolog A S homeolog
thylacine 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001088172.2 → NP_001081641.1  mesoderm posterior homolog A L homeolog

    See identical proteins and their annotated locations for NP_001081641.1

    Status: PROVISIONAL

    Source sequence(s)
    Y14447
    UniProtKB/TrEMBL
    A0A974DE28, B7ZQS7, O73624
    Related
    ENSXLAP00005072644.1, ENSXLAT00005074193.1
    Conserved Domains (1) summary
    pfam00010
    Location:97 → 149
    HLH; Helix-loop-helix DNA-binding domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    114829028..114831404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials