myf5.L myogenic factor 5 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: myf5.L
Official Full Name: myogenic factor 5 L homeolog
Primary source: Xenbase:XB-GENE-866267
Locus tag: XELAEV_18017433mg
See related: EnsemblRapid:ENSXLAG00005004795
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: myf5; Xmyf5; xmyf-5
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Genomic context

Location:: chromosome: 3L

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (59688119..59691151)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (45230032..45233064)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

myf5 upregulation can be a good criterion for the activation of adult myogenesis during X. laevis metamorphosis
Title: Differential muscle regulatory factor gene expression between larval and adult myogenesis in the frog Xenopus laevis: adult myogenic cell-specific myf5 upregulation and its relation to the notochord suppression of adult muscle differentiation.
During early Xenopus development Myf5 protein regulates a distinct myogenic program.
Title: p38 MAP kinase regulates the expression of XMyf5 and affects distinct myogenic programs during Xenopus development.
FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo
Title: FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myogenic factor 5

Names: myf-5; myogenic factor MYF-5; myogenic factor Xmyf-5; myogenic regulatory protein myf-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101779.2 → NP_001095249.1 myogenic factor 5

See identical proteins and their annotated locations for NP_001095249.1

Status: PROVISIONAL

Source sequence(s)

X56738

UniProtKB/Swiss-Prot

P24700

UniProtKB/TrEMBL

A0A974DDM3, B7ZRD6

Related

ENSXLAP00005014279.1, ENSXLAT00005014475.1

Conserved Domains (3) summary

smart00520
Location:1 → 88

BASIC; Basic domain in HLH proteins of MYOD family

pfam00010
Location:84 → 135

HLH; Helix-loop-helix DNA-binding domain

pfam12232
Location:143 → 214

Myf5; Myogenic determination factor 5