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klp6 kinesin-8 family plus-end directed microtubule motor Klp6 [ Schizosaccharomyces pombe (fission yeast) ]

Gene ID: 2539700, updated on 18-Sep-2024

Summary

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Official Symbol
klp6
Official Full Name
kinesin-8 family plus-end directed microtubule motor Klp6
Primary source
PomBase:SPBC1685.15c
Locus tag
SPOM_SPBC1685.15C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Schizosaccharomyces pombe (strain: 972h-)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as
sot2; SPBC649.01c
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Genomic context

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See klp6 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003423.3 (532193..535148, complement)

Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene WD repeat protein, Vid27 family, conserved in fungi and plants Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS19 Neighboring gene DNA repair protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules. Erent M, et al. PLoS One, 2012. PMID 22363481, Free PMC Article
  2. Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles. West RR, et al. Cell Motil Cytoskeleton, 2008 Aug. PMID 18553361, Free PMC Article
  3. Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics. Unsworth A, et al. Mol Biol Cell, 2008 Dec. PMID 18799626, Free PMC Article
  4. Kinesin-8 effects on mitotic microtubule dynamics contribute to spindle function in fission yeast. Gergely ZR, et al. Mol Biol Cell, 2016 Nov 7. PMID 27146110, Free PMC Article
  5. Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement. Grissom PM, et al. Mol Biol Cell, 2009 Feb. PMID 19037096, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We identified an alp7 mutant that had specific defects in binding to the Klp5-Klp6-PP1 complex but with normal localisation to the microtubule and kinetochore.
    Title: Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.
  2. An MT length-dependent increase in the catastrophe frequency is mediated by kinesin-8 proteins (Klp5/6).
    Title: Force- and kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics.
  3. Fission yeast kinesin-8 contributes both to chromosome congression to the metaphase plate and to the coupling of spindle microtubules to kinetochores during anaphase A.
    Title: Kinesin-8 from fission yeast: a heterodimeric, plus-end-directed motor that can couple microtubule depolymerization to cargo movement.
  4. Data suggest that Klp5 and Klp6 play a vital role in promoting microtubule dynamics, which is essential for the spatiotemporal control of microtubule morphogenesis.
    Title: Fission yeast kinesin-8 Klp5 and Klp6 are interdependent for mitotic nuclear retention and required for proper microtubule dynamics.
  5. Data show that Klp6-tail and the neck-tail domains of both motors localized at microtubule ends. Klp6-neck-tail localized to the spindle in early mitosis but to the pole-proximal ends of the spindle in anaphase B.
    Title: Novel interactions of fission yeast kinesin 8 revealed through in vivo expression of truncation alleles.
  6. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast
    Title: The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by PomBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in deactivation of mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic chromosome movement towards spindle pole EXP
Inferred from Experiment
more info
 PubMed 
involved_in mitotic metaphase chromosome recapture IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid biorientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle formation (spindle phase one) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plus-end specific microtubule depolymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport along microtubule to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cortical microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic microtubule plus-end IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol HDA PubMed 
part_of kinesin I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinetochore IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle HDA PubMed 
is_active_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle astral microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle midzone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitotic spindle pole body HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of plus-end kinesin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in post-anaphase microtubule array IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-8 family plus-end directed microtubule motor Klp6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003423.3 Reference assembly

    Range
    532193..535148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001355876.2 → NP_001342739.1  kinesin-8 family plus-end directed microtubule motor Klp6 [Schizosaccharomyces pombe]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O59751, Q9UTZ7
    Conserved Domains (1) summary
    cd01370
    Location:6 → 389
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
Nucleotide Protein
Heading Accession and Version

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