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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
Crotalidae polyvalent immune Fab is used to treat crotalid envenomation (rattlesnakes, copperheads, cottonmouths, water moccasins). No information is available on the clinical use of crotalidae polyvalent immune Fab during breastfeeding. Because it is a large protein molecule, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 [CrossRef]
- 2.
- Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. [PubMed: 33956488]
Substance Identification
Substance Name
Crotalidae Polyvalent Immune Fab
Drug Class
Breast Feeding
Lactation
Milk, Human
Antibodies
Antivenins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- PubMedLinks to PubMed
- Review Crotalidae Polyvalent Immune Fab (Ovine).[Drugs and Lactation Database (...]Review Crotalidae Polyvalent Immune Fab (Ovine).. Drugs and Lactation Database (LactMed®). 2006
- Review Crotalidae Immune F(ab')2 (Equine).[Drugs and Lactation Database (...]Review Crotalidae Immune F(ab')2 (Equine).. Drugs and Lactation Database (LactMed®). 2006
- Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.[Clin Toxicol (Phila). 2022]Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.Spyres MB, Padilla GK, Gerkin RD, Hoyte CO, Wolk BJ, Ruha AM, ToxIC Snakebite Study Group. Clin Toxicol (Phila). 2022 Jul; 60(7):838-842. Epub 2022 Mar 9.
- Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.[Am J Emerg Med. 2021]Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.Martin AM, Wang GS, Poel K. Am J Emerg Med. 2021 Jul; 45:677.e1-677.e3. Epub 2020 Nov 24.
- Rattlesnake venom-induced thrombocytopenia response to Antivenin (Crotalidae) Polyvalent: a case series.[Acad Emerg Med. 2000]Rattlesnake venom-induced thrombocytopenia response to Antivenin (Crotalidae) Polyvalent: a case series.Bush SP, Wu VH, Corbett SW. Acad Emerg Med. 2000 Feb; 7(2):181-5.
- Crotalidae Polyvalent Immune Fab - Drugs and Lactation Database (LactMed®)Crotalidae Polyvalent Immune Fab - Drugs and Lactation Database (LactMed®)
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