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Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-.
Drug Levels and Effects
Summary of Use during Lactation
Crotalidae Immune F(ab')2 (equine) is used to treat crotalid envenomation (rattlesnakes, copperheads, cottonmouths, water moccasins). No information is available on the clinical use of crotalidae antivenin, polyvalent (equine) during breastfeeding. Because it is a mixture of large protein molecule, the amounts in milk are likely to be very low.[1] They are also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] The possibility of sensitization to horse proteins should be kept in mind.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
References
- 1.
- Stratigakis A, Paty D, Zou P, et al. A regression approach for assessing large molecular drug concentration in breast milk. Reprod Breed 2023;3:199-207. doi:10.1016/j.repbre.2023.10.003 [CrossRef]
- 2.
- Anderson PO. Monoclonal antibodies during breastfeeding. Breastfeed Med 2021;16:591-3. [PubMed: 33956488]
Substance Identification
Substance Name
Crotalidae Immune F(ab')2 (Equine)
Drug Class
Breast Feeding
Lactation
Milk, Human
Antibodies
Antivenins
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
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- Review Crotalidae Polyvalent Immune Fab.[Drugs and Lactation Database (...]Review Crotalidae Polyvalent Immune Fab.. Drugs and Lactation Database (LactMed®). 2006
- Review Crotalidae Polyvalent Immune Fab (Ovine).[Drugs and Lactation Database (...]Review Crotalidae Polyvalent Immune Fab (Ovine).. Drugs and Lactation Database (LactMed®). 2006
- Characterization of hypofibrinogenemia following rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom.[Clin Toxicol (Phila). 2024]Characterization of hypofibrinogenemia following rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom.Maciulewicz TS, Axon DR, Shirazi FM. Clin Toxicol (Phila). 2024 Sep 25; :1-5. Epub 2024 Sep 25.
- Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.[Am J Emerg Med. 2021]Use of both Fab and F(ab')(2) fragment antivenom in a pediatric patient for treatment of a North American Crotalidae envenomation.Martin AM, Wang GS, Poel K. Am J Emerg Med. 2021 Jul; 45:677.e1-677.e3. Epub 2020 Nov 24.
- Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.[Clin Toxicol (Phila). 2022]Late hemotoxicity following North American rattlesnake envenomation treated with crotalidae immune F(ab')(2) (equine) antivenom and crotalidae immune polyvalent Fab (ovine) antivenom reported to the North American Snakebite Sub-registry.Spyres MB, Padilla GK, Gerkin RD, Hoyte CO, Wolk BJ, Ruha AM, ToxIC Snakebite Study Group. Clin Toxicol (Phila). 2022 Jul; 60(7):838-842. Epub 2022 Mar 9.
- Crotalidae Immune F(ab')2 (Equine) - Drugs and Lactation Database (LactMed®)Crotalidae Immune F(ab')2 (Equine) - Drugs and Lactation Database (LactMed®)
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