Binding Partners of TRPC Channels and Their Effects on Channel Localization and Function
| Proposed TRPC Binding Partners | Proposed Binding Domain | Functional consequence | |
|---|---|---|---|
| CaBP1 (22) | TRPC5 | C-terminus | inactivation |
| CaM (76) | TRPC1–7 | CIRB; CCB (TRPC1,2,4,5; Drosophila TRP) | inactivation of TRPC |
| Caveolin-1 (8) | TRPC1,3 | TRPC1: aa271–349 | trafficking and anchoring |
| NHERF (36,38) | TRPC4 +ß; TRPC5 | C-terminus | anchoring |
| Homer (72) | TRPC1,2,5 | TRPC1: proline-rich domain+ N-terminus | activation/inactivation |
| Immunophilins (46) | FKBP12: Drosophila TRP, TRPC3,6; FKBP52: TRPC1,4,5 | first dipeptide of proline-rich domain | not determined |
| INAD (26) | Drosophila TRP | C-terminus | anchoring |
| IP3R (52) | TRPC1–7; Drosophila TRP | CIRB | conformational coupling and activation |
| Junctate (48,54) | TRPC2,3,5 | TRPC2: C-terminus | activation |
| NCX (42) | TRPC3 | C-terminus | increased NCX mediated Ca2+ entry |
| PLCy (57) | TRPC3 | TRPC3: aa 40–48 | targeting, anchoring |
| RhoA (35) | TRPC1 | not determined | trafficking |
| Stathmin (14) | TRPC5 | TRPC5: coiled-coil domain in N-terminus | trafficking and targeting |
| VAMP2 (45) | TRPC3 | TRPC3:aa123–221 | trafficking |
| ZO-1 (47) | TRPC4 | C-terminus | targeting |
From: Chapter 24, Protein–Protein Interactions in TRPC Channel Complexes
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