Table 2Structures and activities of analogs 6

Image ml169fu3.jpg
CmpdCIDRM1 EC50 (μM)%ACh Max
6a44247543
Image ml169fu4.jpg
3.21102
6b44216758
Image ml169fu5.jpg
2.1990
6c44475951
Image ml169fu6.jpg
> 10-
6d44241482
Image ml169fu7.jpg
> 10-
6e44216757
Image ml169fu8.jpg
> 10-
6f44475953
Image ml169fu9.jpg
> 10-
6g44475954
Image ml169fu10.jpg
NH > 10-
6h44475952
Image ml169fu11.jpg
> 10-

From: Discovery and development of a second highly selective M1 Positive Allosteric Modulator (PAM)

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].
Copyright Notice

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.