Table 2Plasma Stability and Plasma Protein Binding of ML408 (CID 72725758) and CID 780674

Image ml408fu2.jpg
Image ml408fu3.jpg
PubChem CID
Probe/analogue		72725758
Probe, ML408		780674
HTS Hit
Plasma stability
(% remaining after 5 hours)		Human100100
Murine91.594.9
Plasma protein binding
(% bound)		Human91.294.4
Murine95.795.9

From: Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

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Probe Reports from the NIH Molecular Libraries Program [Internet].
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