Table 8.

Treatment of Manifestations in Individuals with CLCN7-Related Autosomal Dominant Osteopetrosis Type II (ADOII)

Manifestation/ConcernTreatmentConsiderations/Other
Fractures Treatment by orthopedist w/experience w/ADOIIFractures near joints may require total joint arthroplasty [Strickland & Berry 2005].
Arthritis Medical treatment w/anti-inflammatory agents
Anemia & thrombocytopenia Transfusions
Visual impairment Surgical optic nerve decompression
Hearing loss Hearing aids
Dental issues Regular dental care & good oral hygiene

ADOII = autosomal dominant osteopetrosis type II

From: CLCN7-Related Osteopetrosis

Cover of GeneReviews®
GeneReviews® [Internet].
Adam MP, Feldman J, Mirzaa GM, et al., editors.
Seattle (WA): University of Washington, Seattle; 1993-2024.
Copyright © 1993-2024, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.