| Dlec1 is required for spermatogenesis and male fertility in mice. | Dlec1 is required for spermatogenesis and male fertility in mice.
Okitsu Y, Nagano M, Yamagata T, Ito C, Toshimori K, Dohra H, Fujii W, Yogo K., Free PMC Article | 03/13/2021 |
| PM2.5 exposure and DLEC1 promoter methylation in Taiwan Biobank participants. | PM(2.5) exposure and DLEC1 promoter methylation in Taiwan Biobank participants.
Chou YH, Tantoh DM, Wu MC, Tyan YS, Chen PH, Nfor ON, Hsu SY, Shen CY, Huang CN, Liaw YP., Free PMC Article | 11/28/2020 |
| Compared with negative methylation (Nm), DLEC1-positive methylation (Pm) was associated with increased GC risk in PS (OR 2.083, 95% CI 1.220-3.558, P = 0.007), but PBX3 Pm was not associated with GC risk. | Relationship between DLEC1 and PBX3 promoter methylation and the risk and prognosis of gastric cancer in peripheral blood leukocytes.
Xie W, Zhou H, Han Q, Sun T, Nie C, Hong J, Wei R, Leonteva A, Han X, Wang J, Du X, Zhu L, Zhao Y, Tian W, Xue Y. | 04/18/2020 |
| that the KLF4 and DLEC1 genes can be considered potential methylation biomarkers for uterine leiomyomas | Different methylation levels in the KLF4, ATF3 and DLEC1 genes in the myometrium and in corpus uteri mesenchymal tumours as assessed by MS-HRM.
Braný D, Dvorská D, Grendár M, Ňachajová M, Szépe P, Lasabová Z, Žúbor P, Višňovský J, Halášová E. | 01/18/2020 |
| DLEC1 methylation can be utilized to identify a subset with a better prognosis in intrahepatic cholangiocarcinomas of the small duct type. | DLEC1 methylation is associated with a better clinical outcome in patients with intrahepatic cholangiocarcinoma of the small duct subtype.
Kim Y, Lee K, Jeong S, Wen X, Cho NY, Kang GH. | 07/20/2019 |
| We found no correlation between the DLEC1, TUSC4 and MLH1 gene expression and NSCLC patient characteristics (gender, age and smoking) or cancer histopathology. No significant differences in the gene expression among NSCLC subtypes indicate the weakness of DLEC1, TUSC4 and MLH1 expression analysis as potential differentiating markers of NSCLC subtypes in the Polish population. | Small suitability of the DLEC1, MLH1 and TUSC4 mRNA expression analysis as potential prognostic or differentiating markers for NSCLC patients in the Polish population.
Kordiak J, Czarnecka KH, Pastuszak-Lewandoska D, Antczak A, Migdalska-Sęk M, Nawrot E, Domańska-Senderowska D, Kiszałkiewicz J, Brzeziańska-Lasota E. | 04/7/2018 |
| the expression levels of DLEC1 and ITGA9 were prominently decreased in lung tumor samples | Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer.
Pastuszak-Lewandoska D, Kordiak J, Antczak A, Migdalska-Sęk M, Czarnecka KH, Górski P, Nawrot E, Kiszałkiewicz JM, Domańska-Senderowska D, Brzeziańska-Lasota E. | 04/22/2017 |
| DLEC1 mediates tumor-suppressive activities through NF-kappaB signaling. | DLEC1, a 3p tumor suppressor, represses NF-κB signaling and is methylated in prostate cancer.
Zhang L, Zhang Q, Li L, Wang Z, Ying J, Fan Y, He Q, Lv T, Han W, Li J, Yang Y, Xu B, Wang L, Liu Q, Sun Y, Guo Y, Tao Q, Jin J. | 02/6/2016 |
| DLEC1 methylation was not associated with the clinicopathological variables of gastric cancer. | Methylation of DLEC1 promoter is a predictor for recurrence in Chinese patients with gastric cancer.
Ye X, Feng G, Jiao N, Pu C, Zhao G, Sun G., Free PMC Article | 08/1/2015 |
| DLEC1 is down-regulated in head and neck squamous cell tumors and it's promoter methylation is not associated with the clinicopathological parameters. | DLEC1 is not silenced solely by promoter methylation in head and neck squamous cell carcinoma.
Seven D, Yavuz E, Kilic E, Baltaci E, Karaman E, Ulutin T, Buyru N. | 06/27/2015 |
| methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis | Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas.
Wang Z, Li L, Su X, Gao Z, Srivastava G, Murray PG, Ambinder R, Tao Q., Free PMC Article | 04/6/2013 |
| Repression of DLEC1 in squamous cell carcinoma tissues is associated with promoter hypermethylation. DLEC1 is downregulated in sinonasal squamous cell carcinoma and inverted papilloma and has a distinct mechanism. | Downregulation of DLEC1 in sinonasal inverted papilloma and squamous cell carcinoma.
Chang PH, Huang CC, Lee TJ, Lee YS, Tsai CN. | 11/17/2012 |
| Epigenetic inactivation of DLEC1 was crucial in gastric and colorectal carcinogenesis. DLEC1 methylation in serum may be a promise biomarker for GAC and CRAC early diagnosis. | Epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in gastric and colorectal adenocarcinoma.
Zhang Y, Ye X, Geng J, Chen L. | 04/23/2011 |
| results demonstrate that down-expression and promoter methylation of DLEC1 increased from normal tissues to premalignancies and then to malignancies. | Transcriptional repression of DLEC1 associates with the depth of tumor invasion in oral squamous cell carcinoma.
Chan WH, Chang KP, Yang SW, Yao TC, Ko TY, Lee YS, Tsai CL, Tsai CN. | 04/16/2011 |
| Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation is associated with non-small-cell lung cancer. | Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer.
Zhang Y, Miao Y, Yi J, Wang R, Chen L. | 10/23/2010 |
| DLEC1 is often down-regulated by CpG methylation and shows tumor inhibitory function in renal cell carcinoma cells, indicating its role as a tumor suppressor | Aberrant promoter methylation of DLEC1, a critical 3p22 tumor suppressor for renal cell carcinoma, is associated with more advanced tumor stage.
Zhang Q, Ying J, Li J, Fan Y, Poon FF, Ng KM, Tao Q, Jin J. | 08/30/2010 |
| DLEC1 expression levels were significantly lower in samples from patients who developed metastasis, local recurrence, or died of breast cancer when compared to those who were disease free for >10 years. | Evidence of a tumour suppressor function for DLEC1 in human breast cancer.
Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K. | 07/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P. | 04/22/2009 |
| DLEC1 underwent promoter methylation-associated silencing in colon and gastric tumour cell lines and primary tumours. | DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.
Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q., Free PMC Article | 01/21/2010 |
| DLEC1 methylation was an independent marker of poor survival in patients with non-small cell lung carcinoma. | DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma.
Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR., Free PMC Article | 01/21/2010 |
| DLEC1 is a candidate tumor suppressor gene that plays an important role in the development and progression of hepatocellular carcinoma. | The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.
Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, Chen GG, Harrison D, Lai P, Tao Q, Hooi SC. | 01/21/2010 |
| Silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in nasopharyngeal carcinoma tumorigenesis. | Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma.
Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW. | 01/21/2010 |
| DLEC1 suppresses the growth of ovarian cancer cells and its downregulation is closely associated with promoter hypermethylation and histone hypoacetylation | Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer.
Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, Welch WR, Berkowitz RS, Mok SC., Free PMC Article | 01/21/2010 |