| Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L). | Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L).
Wang K, Li B, Fan P, Ren X, Jiang H., Free PMC Article | 02/19/2022 |
| CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. | CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1.
Jokoji G, Maeda S, Oishi K, Ijuin T, Nakajima M, Tawaratsumida H, Kawamura I, Tominaga H, Taketomi E, Ikegawa S, Taniguchi N., Free PMC Article | 12/4/2021 |
| ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L. | ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L.
Liu H, Guo D, Sha Y, Zhang C, Jiang Y, Hong L, Zhang J, Jiang Y, Lu L, Huang H., Free PMC Article | 02/27/2021 |
| One target of CDC5L, ARGN, mediated the strong phenotypic consequences of NEAT1 reduction. | Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit.
Li X, Wang X, Song W, Xu H, Huang R, Wang Y, Zhao W, Xiao Z, Yang X. | 08/31/2019 |
| Study demonstrates that the levels of Prp19 and Cdc5L are overexpressed in hepatocellular carcinoma (HCC). Prp19 binds with Cdc5L and its downregulation results in reduction of Cdc5L. Mechanistic insights reveal that silencing Prp19 compromises translation activity of Cdc5L and facilitates lysosome-induced degradation of Cdc5L in HCC cells. | Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.
Huang R, Xue R, Qu D, Yin J, Shen XZ., Free PMC Article | 04/29/2017 |
| CDC5L might play an important role in glioma cell survival and disease progression. | Expression of CDC5L is associated with tumor progression in gliomas.
Chen W, Zhang L, Wang Y, Sun J, Wang D, Fan S, Ban N, Zhu J, Ji B, Wang Y. | 02/18/2017 |
| Cdc5L was highly expressed in hepatocellular carcinoma. Overexpression of Cdc5L favors cell cycle progress of HCC cells, while downregulation of Cdc5L results in cell cycle arrest at G2/M phase and reduced cell proliferation of HCC cells. | Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma.
Qiu H, Zhang X, Ni W, Shi W, Fan H, Xu J, Chen Y, Ni R, Tao T. | 07/2/2016 |
| The results show that CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex. | CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.
van Maldegem F, Maslen S, Johnson CM, Chandra A, Ganesh K, Skehel M, Rada C., Free PMC Article | 11/28/2015 |
| Cdc5L is a key regulator of mitotic progression. | Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.
Mu R, Wang YB, Wu M, Yang Y, Song W, Li T, Zhang WN, Tan B, Li AL, Wang N, Xia Q, Gong WL, Wang CG, Zhou T, Guo N, Sang ZH, Li HY., Free PMC Article | 05/23/2015 |
| The N-terminal ARM-repeat domain of CTNNBL1 provides a binding site for CDC5L, a binding partner in the Prp19-CDC5L complex. | Structural insights into the novel ARM-repeat protein CTNNBL1 and its association with the hPrp19-CDC5L complex.
Ahn JW, Kim S, Kim EJ, Kim YJ, Kim KJ. | 08/23/2014 |
| CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31 | CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
Ganesh K, Adam S, Taylor B, Simpson P, Rada C, Neuberger M., Free PMC Article | 07/16/2011 |
| Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction | Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
Chen YC, Weinreich M., Free PMC Article | 02/26/2011 |
| A central region in hnRNP-M is required for interaction with CDC5L/PLRG1. | Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.
Llères D, Denegri M, Biggiogera M, Ajuh P, Lamond AI., Free PMC Article | 09/6/2010 |
| Blom7alpha is a novel splicing factor of the K homology domain family that might be implicated in alternative splicing by helping to position the CDC5L-SNEV(Prp19-Pso4) complex at the splice sites | Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
Grillari J, Löscher M, Denegri M, Lee K, Fortschegger K, Eisenhaber F, Ajuh P, Lamond AI, Katinger H, Grillari-Voglauer R., Free PMC Article | 06/8/2010 |
| These findings show a new function for Cdc5L in the regulation of the ATR-mediated cell-cycle checkpoint in response to genotoxic agents. | Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint.
Zhang N, Kaur R, Akhter S, Legerski RJ., Free PMC Article | 01/21/2010 |
| Phosphorylation of CDC5L at threonines 411 and 438 within recognition sequences for CDKs are required for CDC5L-mediated pre-mRNA splicing. | Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.
Gräub R, Lancero H, Pedersen A, Chu M, Padmanabhan K, Xu XQ, Spitz P, Chalkley R, Burlingame AL, Stokoe D, Bernstein HS., Free PMC Article | 01/21/2010 |
| Results indicate that CDC5L is the most likely candidate oncogene for the 6p12-p21 amplicon found in osteosarcoma. | Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma.
Lu XY, Lu Y, Zhao YJ, Jaeweon K, Kang J, Xiao-Nan L, Ge G, Meyer R, Perlaky L, Hicks J, Chintagumpala M, Cai WW, Ladanyi M, Gorlick R, Lau CC, Pati D, Sheldon M, Rao PH., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCoeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C. Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine.
Jarjanazi H, Kiefer J, Savas S, Briollais L, Tuzmen S, Pabalan N, Ibrahim-Zada I, Mousses S, Ozcelik H. | 04/3/2008 |
| the interaction between CDC5L and PLRG1 is essential for pre-mRNA splicing | Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1.
Ajuh P, Lamond AI., Free PMC Article | 01/21/2010 |
| CDC5 may function in pre-mRNA processing and cell cycle progression | Distinct domains of human CDC5 direct its nuclear import and association with the spliceosome.
Liu L, Gräub R, Hlaing M, Epting CL, Turck CW, Xu XQ, Zhang L, Bernstein HS. | 01/21/2010 |