| FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism. | FGL1: a novel biomarker and target for non-small cell lung cancer, promoting tumor progression and metastasis through KDM4A/STAT3 transcription mechanism.
Liu TY, Yan JS, Li X, Xu L, Hao JL, Zhao SY, Hu QL, Na FJ, Li HM, Zhao Y, Zhao MF., Free PMC Article | 09/10/2024 |
| JMJD2A promotes the development of castration-resistant prostate cancer by activating androgen receptor enhancer and inhibiting the cGAS-STING pathway. | JMJD2A promotes the development of castration-resistant prostate cancer by activating androgen receptor enhancer and inhibiting the cGAS-STING pathway.
Cai X, Yu X, Tang T, Xu Y, Wu T. | 08/27/2024 |
| The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma. | The role of JMJD2A in immune evasion and malignant behavior of esophageal squamous cell carcinoma.
Su X, Ding X, Ding C, Wang G, Fu C, Liu F, Shi J, He W. | 08/5/2024 |
| The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis. | The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
Li XX, Xu JK, Su WJ, Wu HL, Zhao K, Zhang CM, Chen XK, Yang LX. | 02/9/2024 |
| SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A. | SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.
Gu R, Kim TD, Song H, Sui Y, Shin S, Oh S, Janknecht R., Free PMC Article | 11/10/2023 |
| Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1. | Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1.
Hou Y, Yu W, Wu G, Wang Z, Leng S, Dong M, Li N, Chen L., Free PMC Article | 08/10/2023 |
| JMJD2A participates in cytoskeletal remodeling to regulate castration-resistant prostate cancer docetaxel resistance. | JMJD2A participates in cytoskeletal remodeling to regulate castration-resistant prostate cancer docetaxel resistance.
Cai X, Duan X, Tang T, Cui S, Wu T., Free PMC Article | 05/17/2023 |
| SUMO Modification of Histone Demethylase KDM4A in Kaposi's Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma. | SUMO Modification of Histone Demethylase KDM4A in Kaposi's Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.
Yeh WW, Chen YQ, Yang WS, Hong YC, Kao S, Liu TT, Chen TW, Chang L, Chang PC., Free PMC Article | 09/3/2022 |
| Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis. | Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.
Xu Y, Qian C, Liu C, Fu Y, Zhu K, Niu Z, Liu J., Free PMC Article | 07/23/2022 |
| Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion. | Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion.
Zhao J, Li B, Ren Y, Liang T, Wang J, Zhai S, Zhang X, Zhou P, Zhang X, Pan Y, Gao F, Zhang S, Li L, Yang Y, Deng X, Li X, Chen L, Yang D, Zheng Y., Free PMC Article | 03/26/2022 |
| Mechanistic insights into KDM4A driven genomic instability. | Mechanistic insights into KDM4A driven genomic instability.
Young NL, Dere R., Free PMC Article | 01/29/2022 |
| Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). | Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
Lapidot M, Case AE, Weisberg EL, Meng C, Walker SR, Garg S, Ni W, Podar K, Hung YP, Carrasco RD, Knott A, Gokhale PC, Sharma S, Pozhitkov A, Kulkarni P, Frank DA, Salgia R, Griffin JD, Saladi SV, Bueno R, Sattler M., Free PMC Article | 12/18/2021 |
| Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development. | Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development.
Zhu HY, Kang XJ, Jin L, Zhang PY, Wu H, Tan T, Yu Y, Fan Y., Free PMC Article | 11/27/2021 |
| KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors. | KDM4A regulates myogenesis by demethylating H3K9me3 of myogenic regulatory factors.
Zhu Q, Liang F, Cai S, Luo X, Duo T, Liang Z, He Z, Chen Y, Mo D., Free PMC Article | 10/16/2021 |
| Long non-coding RNA KIKAT/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation. | Long non-coding RNA KIKAT/LINC01061 as a novel epigenetic regulator that relocates KDM4A on chromatin and modulates viral reactivation.
Yang WS, Yeh WW, Campbell M, Chang L, Chang PC., Free PMC Article | 10/9/2021 |
| KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma. | KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma.
Chen M, Jiang Y, Sun Y. | 06/26/2021 |
| Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress. | Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress.
Zhang W, Liu W, Jia L, Chen D, Chang I, Lake M, Bentolila LA, Wang CY., Free PMC Article | 06/19/2021 |
| Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation. | Fisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation.
Ding G, Xu X, Li D, Chen Y, Wang W, Ping D, Jia S, Cao L., Free PMC Article | 04/13/2021 |
| JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8. | JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8.
Nakagawa T, Sato Y, Tanahashi T, Mitsui Y, Kida Y, Fujino Y, Hirata M, Kitamura S, Miyamoto H, Okamoto K, Muguruma N, Bando Y, Takayama T. | 03/20/2021 |
| RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A. | RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS., Free PMC Article | 03/13/2021 |
| The expression of JMJD2A is upregulated in ovarian cancer cells and tissues. JMJD2A upregulates expression of both interleukin-6 and interleukin-8 and increases the stability of interleukin-8 mRNa. | IL-6 and IL-8 are involved in JMJD2A-regulated malignancy of ovarian cancer cells.
Zhang H, Wang Z, Wang F, Wang C, Zhang H. | 07/18/2020 |
| The relationship between the lncRNA model and prognosis as well as clinical characteristics of patients with HCC was analyzed. Finally, a predictive nomogram in the the cancer genome atlas cohort was established and verified internallyBased on the RNA sequencing survival analysis, a 9- lncRNAs prognosis model, including TMCC1-AS1, AC008892.1, AL031985.3, L34079.2, U95743.1, KDM4A-AS1, SACS-AS1, AC005534.1, LINC01116. | Development and validation of 9-long Non-coding RNA signature to predicting survival in hepatocellular carcinoma.
Deng B, Yang M, Wang M, Liu Z., Free PMC Article | 06/20/2020 |
| results uncovered a tumor suppressor role of miR-10a in PCa via negative regulation of KDM4A and its downstream Hippo-YAP pathway. | MiR-10a functions as a tumor suppressor in prostate cancer via targeting KDM4A.
Mu H, Xiang L, Li S, Rao D, Wang S, Yu K. | 06/20/2020 |
| At levels of condFDR < 0:01 and conjFDR < 0:05; we identified 5 ADHD-associated loci, 3 of these being shared between ADHD and EA. | Novel Loci Associated With Attention-Deficit/Hyperactivity Disorder Are Revealed by Leveraging Polygenic Overlap With Educational Attainment.
Shadrin AA, Smeland OB, Zayats T, Schork AJ, Frei O, Bettella F, Witoelar A, Li W, Eriksen JA, Krull F, Djurovic S, Faraone SV, Reichborn-Kjennerud T, Thompson WK, Johansson S, Haavik J, Dale AM, Wang Y, Andreassen OA., Free PMC Article | 11/2/2019 |
| It was determined that JMJD2A promoted EMT through regulation of SLUG expression. Findings revealed that JMJD2A may act as an oncogene and participate in bladder cancer progression. | Upregulation of JMJD2A promotes migration and invasion in bladder cancer through regulation of SLUG.
Wang F, Li Y, Shan F, Zhang Q, Wang L, Sheng B, Cheng G. | 10/26/2019 |