| The BHLHE40-PPM1F-AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer. | The BHLHE40‒PPM1F‒AMPK pathway regulates energy metabolism and is associated with the aggressiveness of endometrial cancer.
Asanoma K, Yagi H, Onoyama I, Cui L, Hori E, Kawakami M, Maenohara S, Hachisuga K, Tomonobe H, Kodama K, Yasunaga M, Ohgami T, Okugawa K, Yahata H, Kitao H, Kato K., Free PMC Article | 04/10/2024 |
| Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. | Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus.
Zhang C, Han X, Yang L, Fu J, Sun C, Huang S, Xiao W, Gao Y, Liang Q, Wang X, Luo F, Lu W, Zhou Y., Free PMC Article | 06/5/2021 |
| PPM1F controls integrin activity via a conserved phospho-switch. | PPM1F controls integrin activity via a conserved phospho-switch.
Grimm TM, Dierdorf NI, Betz K, Paone C, Hauck CR., Free PMC Article | 04/3/2021 |
| Phosphatase POPX2 interferes with cell cycle by interacting with Chk1. | Phosphatase POPX2 interferes with cell cycle by interacting with Chk1.
Kim PR, Koon YL, Lee RTC, Azizan F, Koh DHZ, Chiam KH, Koh CG., Free PMC Article | 02/2/2021 |
| results extend prior work linking PPM1F to Post Traumatic Stress Disorder and suggest that variants in this gene may have bearing on the neural integrity of the prefrontal cortex. | The PPM1F gene moderates the association between PTSD and cortical thickness.
Sullivan DR, Morrison FG, Wolf EJ, Logue MW, Fortier CB, Salat DH, Fonda JR, Stone A, Schichman S, Milberg W, McGlinchey R, Miller MW., Free PMC Article | 07/18/2020 |
| PPM1F is involved in stress- and trauma-related manifestation of anxiety and depression. | Expression of the PPM1F Gene Is Regulated by Stress and Associated With Anxiety and Depression.
Wingo AP, Velasco ER, Florido A, Lori A, Choi DC, Jovanovic T, Ressler KJ, Andero R., Free PMC Article | 05/4/2019 |
| our findings demonstrated that low expression of miR-490-3p or high expression of PPM1F was positively associated with poor survival and tumor recurrence in patients with HCC, and miR-490-3p suppressed cell proliferation and invasion by targeting PPM1F. | CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.
Wang H, Chen W, Jin M, Hou L, Chen X, Zhang R, Zhang J, Zhu J., Free PMC Article | 04/27/2019 |
| PPM1F overexpression suppressed cell proliferation and invasion and counteracted the tumour-promoting role of miR-590, but PPM1F knockdown reversed these effects. | Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer.
Zhang J, Jin M, Chen X, Zhang R, Huang Y, Liu H, Zhu J., Free PMC Article | 09/1/2018 |
| POPX2 is a negative regulator of TAK1 signaling pathway and modulates apoptosis through the regulation of TAK1 activity. | POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway.
Weng T, Koh CG., Free PMC Article | 06/9/2018 |
| PPM1F could work downstream of alpha9-nAchR to promote nicotine-induced carcinogenic signals. Thus, PPM1F expression could be used for prognostic diagnosis, or inhibited as a potential strategy for cancer prevention and therapy. | Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals.
Tu SH, Lin YC, Huang CC, Yang PS, Chang HW, Chang CH, Wu CH, Chen LC, Ho YS., Free PMC Article | 03/3/2018 |
| This study, combined with our previous findings, suggests that a single ubiquitously expressed phosphatase POPX2 influences cancer metastasis via modulating multiple biological processes including MAPK signaling and exosome cytokine secretion. | Phosphatase POPX2 Exhibits Dual Regulatory Functions in Cancer Metastasis.
Zhang S, Weng T, Cheruba E, Guo T, Chan H, Sze SK, Koh CG. | 10/14/2017 |
| Overexpression of PPM1F is associated with metastasis of hepatocellular carcinoma. | miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.
Luo G, Chao YL, Tang B, Li BS, Xiao YF, Xie R, Wang SM, Wu YY, Dong H, Liu XD, Yang SM., Free PMC Article | 09/24/2016 |
| POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. | POPX2 phosphatase regulates the KIF3 kinesin motor complex.
Phang HQ, Hoon JL, Lai SK, Zeng Y, Chiam KH, Li HY, Koh CG. | 10/11/2014 |
| POPX2 might regulate cell motility through its regulation of the MAPK1/3, leading to changes in the cytoskeleton and cell motility. | Integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase.
Zhang S, Guo T, Chan H, Sze SK, Koh CG. | 12/28/2013 |
| hCaMKP activity is reversibly regulated by oxidation/reduction at Cys-359 | Regulation of Ca(2+)/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359.
Baba H, Sueyoshi N, Shigeri Y, Ishida A, Kameshita I. | 11/3/2012 |
| FHOD1 and PPM1F (direct regulators of the actin cytoskeleton) were identified as novel targets of miR-200c. Expression levels of FHOD1 and PPM1F were inversely correlated with miR-200c level in breast cancer cell lines and breast cancer patient samples. | MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F.
Jurmeister S, Baumann M, Balwierz A, Keklikoglou I, Ward A, Uhlmann S, Zhang JD, Wiemann S, Sahin Ö., Free PMC Article | 03/17/2012 |
| Data identify a biochemical pathway through which POPX2 exerts its apparent cellular function: the regulation of activity of glycogen synthase kinase-3, which in turn modulates extracellular signal-regulated kinase and cell motility. | Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis.
Singh P, Gan CS, Guo T, Phang HQ, Sze SK, Koh CG. | 10/29/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The POPX2 phosphatase regulates cancer cell motility and invasiveness. | The POPX2 phosphatase regulates cancer cell motility and invasiveness.
Susila A, Chan H, Loh AX, Phang HQ, Wong ET, Tergaonkar V, Koh CG. | 03/15/2010 |
| PPM1F plays a key role in the regulation of CaMKII intracellularly | Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts.
Harvey BP, Banga SS, Ozer HL. | 01/21/2010 |
| The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (POPX1; POPX2) | The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family.
Koh CG, Tan EJ, Manser E, Lim L. | 01/21/2010 |