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    CD27 CD27 molecule [ Homo sapiens (human) ]

    Gene ID: 939, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Comprehensive Analysis of Expression and Pathway for CD27 in Esophageal Cancer.

    Comprehensive Analysis of Expression and Pathway for CD27 in Esophageal Cancer.
    Xiao FK, Wang L.

    09/5/2024
    Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma.

    Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma.
    Nagato T, Komatsuda H, Hayashi R, Takahara M, Ujiie N, Kosaka A, Ohkuri T, Oikawa K, Sato R, Wakisaka R, Kono M, Yamaki H, Ohara K, Kumai T, Kishibe K, Katada A, Hayashi T, Kobayashi H., Free PMC Article

    04/24/2024
    Cerebrospinal fluid soluble CD27 is associated with CD8[+] T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis.

    Cerebrospinal fluid soluble CD27 is associated with CD8(+) T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis.
    El Mahdaoui S, Husted SR, Hansen MB, Cobanovic S, Mahler MR, Buhelt S, von Essen MR, Sellebjerg F, Romme Christensen J.

    11/10/2023
    CD27 on human memory B cells-more than just a surface marker.

    CD27 on human memory B cells-more than just a surface marker.
    Grimsholm O., Free PMC Article

    07/26/2023
    Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.

    Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
    Bowakim-Anta N, Acolty V, Azouz A, Yagita H, Leo O, Goriely S, Oldenhove G, Moser M., Free PMC Article

    04/6/2023
    Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.

    Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.
    Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N.

    10/15/2022
    Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients.

    Early detection of soluble CD27, BTLA, and TIM-3 predicts the development of nosocomial infection in pediatric burn patients.
    Penatzer JA, Alexander R, Simon S, Wolfe A, Breuer J, Hensley J, Fabia R, Hall M, Thakkar RK., Free PMC Article

    08/27/2022
    CD27 mRNA expression in mycosis fungoides.

    CD27 mRNA expression in mycosis fungoides.
    Galliano I, Daprà V, Ponti R, Alliaudi C, Fierro MT, Quaglino P, Bergallo M.

    07/2/2022
    The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells.

    The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells.
    Kibler A, Budeus B, Küppers R, Seifert M., Free PMC Article

    03/19/2022
    CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion.

    CD27 is required for protective lytic EBV antigen-specific CD8+ T-cell expansion.
    Deng Y, Chatterjee B, Zens K, Zdimerova H, Müller A, Schuhmachers P, Ligeon LA, Bongiovanni A, Capaul R, Zbinden A, Holler A, Stauss H, Hammerschmidt W, Münz C., Free PMC Article

    12/4/2021
    Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.

    Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex.
    Liu W, Maben Z, Wang C, Lindquist KC, Li M, Rayannavar V, Lopez Armenta I, Nager A, Pascua E, Dominik PK, Oyen D, Wang H, Roach RC, Allan CM, Mosyak L, Chaparro-Riggers J., Free PMC Article

    11/27/2021
    CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.

    CD27 enhances the killing effect of CAR T cells targeting trophoblast cell surface antigen 2 in the treatment of solid tumors.
    Chen H, Wei F, Yin M, Zhao Q, Liu Z, Yu B, Huang Z., Free PMC Article

    06/26/2021
    Genetic association study of interferon lambda 3, CD27, and human leukocyte antigen-DPB1 with dengue severity in Thailand.

    Genetic association study of interferon lambda 3, CD27, and human leukocyte antigen-DPB1 with dengue severity in Thailand.
    Arayasongsak U, Naka I, Ohashi J, Patarapotikul J, Nuchnoi P, Kalambaheti T, Sa-Ngasang A, Chanama S, Chaorattanakawee S., Free PMC Article

    03/28/2021
    Prediagnostic serum sCD27 and sCD30 in serial samples and risks of non-Hodgkin lymphoma subtypes.

    Prediagnostic serum sCD27 and sCD30 in serial samples and risks of non-Hodgkin lymphoma subtypes.
    Purdue MP, Lan Q, Langseth H, Grimsrud TK, Hildesheim A, Rothman N., Free PMC Article

    03/13/2021
    CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients.

    CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients.
    von Borstel A, Land J, Abdulahad WH, Rutgers A, Stegeman CA, Diepstra A, Heeringa P, Sanders JS., Free PMC Article

    10/31/2020
    Elevated proportion of CD27 in T cells may contribute to distinct immune pathogenesis for different severities of AA

    Increased CD8(+)CD27(+)perforin(+) T cells and decreased CD8(+)CD70(+) T cells may be immune biomarkers for aplastic anemia severity.
    Zhao S, Zhang Y, Huang G, Luo W, Li Y, Xiao Y, Zhou M, Li Y, Lai J, Li Y, Li B.

    01/18/2020
    anti-CD40 and IL-21 induced normal and even higher levels of Bcl-XL, respectively, in CD27(+) B cells from AP-CVID, which was accompanied by cell viability increase. Thus low-survival memory B cells from AP-CVID can overcome their cell death regulation defects through pro-survival signals provided by T cells. In conclusion, we identify apoptosis regulation defects as disease-contributing factors in CVID.

    IL-21 and anti-CD40 restore Bcl-2 family protein imbalance in vitro in low-survival CD27(+) B cells from CVID patients.
    López-Gómez A, Clemente A, Cunill V, Pons J, Ferrer JM., Free PMC Article

    12/14/2019
    The level of cerebrospinal fluid CD27 was elevated in neuromyelitis optical spectrum disorder patients and correlated with disease activity.

    Cerebrospinal Fluid Level of Soluble CD27 Is Associated with Disease Severity in Neuromyelitis Optica Spectrum Disorder.
    Liu B, Zhong X, Lu Z, Qiu W, Hu X, Wang H.

    09/28/2019
    Study findings suggest that soluble CD27 (sCD27) is a disease marker for non-Hodgkin lymphoma (NHL) and add to the weight of evidence that elevated circulating soluble CD30 (sCD30) is a marker of increased NHL susceptibility.

    Circulating sCD27 and sCD30 in pre-diagnostic samples collected fifteen years apart and future non-Hodgkin lymphoma risk.
    Purdue MP, Lan Q, Hoffman-Bolton J, Hildesheim A, Callahan CL, Strickland P, Visvanathan K, Rothman N., Free PMC Article

    07/13/2019
    Results suggests that CD27 could be a marker for poor prognosis for non-ETV6-RUNX1 B-cell precursor acute lymphoblastic leukemia.

    CD27 expression and its association with clinical outcome in children and adults with pro-B acute lymphoblastic leukemia.
    Chen D, Gerasimčik N, Camponeschi A, Tan Y, Wu Q, Brynjolfsson S, Zheng J, Abrahamsson J, Nordlund J, Lönnerholm G, Fogelstrand L, Mårtensson IL., Free PMC Article

    09/22/2018
    The authors observed differential expression of CD95(Fas) in CD27(+) B-cells from cirrhotic patients that was inversely correlated with peripheral CD27(+) B-cell frequency. They conclude that peripheral CD27(+) memory B-cells in cirrhosis exhibit increased sensitivity to Fas-induced apoptosis in an activation-dependent manner to which endotoxin contributes, associated with reduced frequency of circulating memory B-cells.

    Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis.
    Chang LY, Li Y, Kaplan DE., Free PMC Article

    05/12/2018
    Preclinical testing supports the safety and efficacy of a CD27-containing CAR targeting CD70-expressing tumors

    Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers.
    Wang QJ, Yu Z, Hanada KI, Patel K, Kleiner D, Restifo NP, Yang JC., Free PMC Article

    02/24/2018
    Crystal structure of CD27 in complex with a neutralizing noncompeting antibody has been reported.

    Crystal structure of CD27 in complex with a neutralizing noncompeting antibody.
    Teplyakov A, Obmolova G, Malia TJ, Gilliland GL., Free PMC Article

    12/9/2017
    High CD27 expression is associated with B-cell Lymphoma.

    Biomarker Dynamics in B-cell Lymphoma: A Longitudinal Prospective Study of Plasma Samples Up to 25 Years before Diagnosis.
    Späth F, Wibom C, Krop EJ, Johansson AS, Bergdahl IA, Vermeulen R, Melin B.

    09/9/2017
    activated CD70-expressing lymphocytes may trigger CD27 on AML blasts or stem/progenitor cells

    CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia.
    Riether C, Schürch CM, Bührer ED, Hinterbrandner M, Huguenin AL, Hoepner S, Zlobec I, Pabst T, Radpour R, Ochsenbein AF., Free PMC Article

    08/19/2017
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