| GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors. | GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.
Ahmad R, Lahuna O, Sidibe A, Daulat A, Zhang Q, Luka M, Guillaume JL, Gallet S, Guillonneau F, Hamroune J, Polo S, Prévot V, Delagrange P, Dam J, Jockers R., Free PMC Article | 11/28/2020 |
| GPR50 promoter methylation level was decreased in the male Alzheimer's disease group compared with the male control group. | Significant association between GPR50 hypomethylation and AD in males.
Chen W, Ji H, Li L, Xu C, Zou T, Cui W, Xu S, Zhou X, Duan S, Wang Q., Free PMC Article | 01/4/2020 |
| GPR50 is a TbetaRI co-receptor with potential impact on cancer development | The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.
Wojciech S, Ahmad R, Belaid-Choucair Z, Journé AS, Gallet S, Dam J, Daulat A, Ndiaye-Lobry D, Lahuna O, Karamitri A, Guillaume JL, Do Cruzeiro M, Guillonneau F, Saade A, Clément N, Courivaud T, Kaabi N, Tadagaki K, Delagrange P, Prévot V, Hermine O, Prunier C, Jockers R., Free PMC Article | 12/29/2018 |
| Pre-eclampsia (PE) plasma IgG1 anti-Epstein-Barr virus nuclear antigen 1 (EBNA-1) antibody cross-reacts with placental protein G protein-coupled receptor 50 (GPR50). | A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50.
Elliott SE, Parchim NF, Kellems RE, Xia Y, Soffici AR, Daugherty PS. | 04/1/2017 |
| The results provide deeper insight into the functional evolution of GPR50 in mammals at the molecular level | Uneven evolutionary rate of the melatonin-related receptor gene (GPR50) in primates.
Zhang Y, Li HQ, Yao YF, Liu W, Ni QY, Zhang MW, Xu HL. | 02/6/2016 |
| There was only weak female-specific association between GPR50 variants in late-life depression. No significant associations were observed in men. | Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort.
Ryan J, Carrière I, Ritchie K, Ancelin ML., Free PMC Article | 07/25/2015 |
| study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 in females. | Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern.
Delavest M, Even C, Benjemaa N, Poirier MF, Jockers R, Krebs MO. | 11/17/2012 |
| Positive expression of melatonin receptor can be found in human hypertrophic scar and normal skin, but it is higher in scar. | [The expression of melatonin receptor in human hypertrophic scar].
Zhang JC, Xie YF, Liu SJ, Dai LB, Li JP. | 10/1/2011 |
| we found 2 polymorphisms in the GPR50 receptor of patients with adolescent idiopathic scoliosis, but they were not present at a highly significant frequency when compared with controls | Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.
Shyy W, Wang K, Gurnett CA, Dobbs MB, Miller NH, Wise C, Sheffield VC, Morcuende JA, Shyy W, Wang K, Gurnett CA, Dobbs MB, Miller NH, Wise C, Sheffield VC, Morcuende JA., Free PMC Articles: PMC2928583, PMC2928583 | 01/1/2011 |
| Antibodies were used to study the expression of GPR50 in mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was observed in dorsomedial hypothalamic (DMH) cells and in cells of the ependymal layer of the third ventricle of the hypothalamus. | Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence.
Sidibe A, Mullier A, Chen P, Baroncini M, Boutin JA, Delagrange P, Prevot V, Jockers R. | 08/16/2010 |
| This is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. | Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population.
Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH, Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH. | 07/5/2010 |
| Results identify neurite outgrowth inhibitor NOGO-A as an interacting partner of GPR50 and found an enrichment of both Gpr50 and neuronal Nogo-A at the synapse. | GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.
Grünewald E, Kinnell HL, Porteous DJ, Thomson PA. | 04/12/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.
Ji LD, Xu J, Wu DD, Xie SD, Tang NL, Zhang YP. | 04/7/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (9) articlesEvaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.
Shyy W, Wang K, Gurnett CA, Dobbs MB, Miller NH, Wise C, Sheffield VC, Morcuende JA, Shyy W, Wang K, Gurnett CA, Dobbs MB, Miller NH, Wise C, Sheffield VC, Morcuende JA. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.
Chaste P, Clement N, Mercati O, Guillaume JL, Delorme R, Botros HG, Pagan C, Périvier S, Scheid I, Nygren G, Anckarsäter H, Rastam M, Ståhlberg O, Gillberg C, Serrano E, Lemière N, Launay JM, Mouren-Simeoni MC, Leboyer M, Gillberg C, Jockers R, Bourgeron T. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T. Mutation screening of melatonin-related genes in patients with autism spectrum disorders.
Jonsson L, Ljunggren E, Bremer A, Pedersen C, Landén M, Thuresson K, Giacobini M, Melke J. Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population.
Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH, Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH. Poor replication of candidate genes for major depressive disorder using genome-wide association data.
Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, van Veen T, Willemsen G, DeRijk RH, de Geus EJ, Hoogendijk WJ, Sullivan PF, Penninx BW, Boomsma DI, Snieder H, Nolen WA. GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families.
Feng Y, Wigg K, King N, Vetró A, Kiss E, Kapornai K, Mayer L, Gádoros J, Kennedy JL, Kovacs M, Barr CL, International Consortium for Childhood-Onset Mood Disorders, Feng Y, Wigg K, King N, Vetró A, Kiss E, Kapornai K, Mayer L, Gádoros J, Kennedy JL, Kovacs M, Barr CL, International Consortium for Childhood-Onset Mood Disorders. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.
Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S, Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ, Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ. | 03/13/2008 |
| No evidence for an association for this gene with mood disorders in a Hungarian population. | GPR50 is not associated with childhood-onset mood disorders in a large sample of Hungarian families.
Feng Y, Wigg K, King N, Vetró A, Kiss E, Kapornai K, Mayer L, Gádoros J, Kennedy JL, Kovacs M, Barr CL, International Consortium for Childhood-Onset Mood Disorders, Feng Y, Wigg K, King N, Vetró A, Kiss E, Kapornai K, Mayer L, Gádoros J, Kennedy JL, Kovacs M, Barr CL, International Consortium for Childhood-Onset Mood Disorders. | 01/21/2010 |
| GPR50, an orphan GPCR, heterodimerizes constitutively and specifically with MT(1) and MT(2) melatonin receptors | The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.
Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, Jockers R., Free PMC Article | 01/21/2010 |
| Results describe sequence variants in the melatonin-related receptor gene (GPR50) that associate with circulating triglyceride and HDL levels. | Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.
Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S, Bhattacharyya S, Luan J, Challis B, Keogh J, Montague C, Brennand J, Morten J, Lowenbeim S, Jenkins S, Farooqi IS, Wareham NJ, O'Rahilly S. | 01/21/2010 |
| Polymorphisms in GPR50 were compared in bipolar affective disorder (BD), major depressive disorder (MDD), schizophrenia (SCZ) and controls. GPR50(Delta502-505) or a variant is a sex-specific risk factor for susceptibility to BD and SCZ. | Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.
Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ, Thomson PA, Wray NR, Thomson AM, Dunbar DR, Grassie MA, Condie A, Walker MT, Smith DJ, Pulford DJ, Muir W, Blackwood DH, Porteous DJ. | 01/21/2010 |