Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study. | Whole Genome Linkage and Association Analyses Identify DLG Associated Protein-1 as a Novel Positional and Biological Candidate Gene for Muscle Strength: The Long Life Family Study. Santanasto AJ, Acharya S, Wojczynski MK, Cvejkus RK, Lin S, Brent MR, Anema JA, Wang L, Thyagarajan B, Christensen K, Daw EW, Zmuda JM., | 08/1/2024 |
Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small Cell Lung Cancer. | Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small Cell Lung Cancer. Świtlik W, Wyżewski Z, Gregorczyk-Zboroch K, Gietler M, Pudlarz A, Szewińska J, Orzechowski S, Jakieła S, Szemraj J. | 07/5/2024 |
DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer. | DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer. Liang X, Zhao Y, Fang Z, Shao N, Zhai D, Zhang M, Yu L, Shi Y. | 06/18/2022 |
N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop. | N(6)-methyladenosine (m(6)A)-mediated lncRNA DLGAP1-AS1enhances breast canceradriamycin resistance through miR-299-3p/WTAP feedback loop. Huang T, Cao L, Feng N, Xu B, Dong Y, Wang M., Free PMC Article | 02/19/2022 |
A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. | A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population. Takahashi Y, Yamazaki K, Kamatani Y, Kubo M, Matsuda K, Asai S., Free PMC Article | 01/1/2022 |
LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression. | LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression. Miao W, Li N, Gu B, Yi G, Su Z, Cheng H. | 12/26/2020 |
The top SNP rs2049161 involved gene DLGAP1 and the top gene CADPS2 in the gene-based analysis resulted in much literature evidence of associations with psychiatric disorders. Gene expression and network analysis showed their contribution to cognition function. | Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level. Zhang K, Fan Z, Wang Y, Faraone SV, Yang L, Chang S., Free PMC Article | 08/13/2020 |
We demonstrated that miR-148a was upregulated, DLGAP1 was downregulated in glioblastoma, and DLGAP1 was a direct target of miR-148a. | The role of microRNA-148a and downstream DLGAP1 on the molecular regulation and tumor progression on human glioblastoma. Li Y, Li W, Zeng X, Tang X, Zhang S, Zhong F, Peng X, Zhong Y, Rosol TJ, Deng X, Liu Z, Peng S, Peng X. | 02/29/2020 |
Study presents evidence that the expression of GKAP modulates the activity of the glutamate-to-NMDAR signaling pathway and promotes invasiveness in mouse neuroendocrine (PanNET) and in both mouse and human ductal (PDAC) cancer cell lines. | GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth. Li L, Zeng Q, Bhutkar A, Galván JA, Karamitopoulou E, Noordermeer D, Peng MW, Piersigilli A, Perren A, Zlobec I, Robinson H, Iruela-Arispe ML, Hanahan D., Free PMC Article | 03/2/2019 |
Association of two significant SNPs of DLGAP1 with cognitive flexibility in Attention Deficit Hyperactivity Disorder was observed. | DLGAP1 and NMDA receptor-associated postsynaptic density protein genes influence executive function in attention deficit hyperactivity disorder. Fan Z, Qian Y, Lu Q, Wang Y, Chang S, Yang L., Free PMC Article | 02/9/2019 |
This study revealed a significant variant (rs12455524) within the gene DLGAP1 for Recurrent major depression. | Recurrent major depression and right hippocampal volume: A bivariate linkage and association study. Mathias SR, Knowles EE, Kent JW Jr, McKay DR, Curran JE, de Almeida MA, Dyer TD, Göring HH, Olvera RL, Duggirala R, Fox PT, Almasy L, Blangero J, Glahn DC., Free PMC Article | 10/22/2016 |
These results strongly suggested involvement of the DLGAP1 gene product in the development of HIV-related lipoatrophy in Thai HIV patients. | Genome-Wide Association Study of HIV-Related Lipoatrophy in Thai Patients: Association of a DLGAP1 Polymorphism with Fat Loss. Uttayamakul S, Oudot-Mellakh T, Nakayama EE, Tengtrakulcharoen P, Guergnon J, Delfraissy JF, Khusmith S, Sangsajja C, Likanonsakul S, Theodorou I, Shioda T., Free PMC Article | 04/30/2016 |
This study showed that DLGAP1 association with obsessive-compulsive disorder. | Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, Geller DA, Murphy DL, Knowles JA, Grados MA, Riddle MA, Rasmussen SA, McLaughlin NC, Nurmi EL, Askland KD, Qin HD, Cullen BA, Piacentini J, Pauls DL, Bienvenu OJ, Stewart SE, Liang KY, Goes FS, Maher B, Pulver AE, Shugart YY, Valle D, Lange C, Nestadt G., Free PMC Article | 03/5/2016 |
Dimerization of DLC2 was required for its interaction with GKAP, which, in turn, potentiated GKAP self-association. | The stoichiometry of scaffold complexes in living neurons - DLC2 functions as a dimerization engine for GKAP. Moutin E, Compan V, Raynaud F, Clerté C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J. | 05/16/2015 |
Results show that the expression and distribution of NMDA receptors subunits GluN1, GluN2A and GluN2B - together with that of postsynaptic protein PSD-95 - are modified in Alzheimer's disease compared to normal aging | Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease. Leuba G, Vernay A, Kraftsik R, Tardif E, Riederer BM, Savioz A. | 10/4/2014 |
dlgap1 showed the highest association, of snps examined, with ocd. | Genome-wide association study of obsessive-compulsive disorder. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH Jr, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, North American Brain Expression Consortium, Hardy J, UK Brain Expression Database, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL., Free PMC Article | 05/3/2014 |
Study identified six genetic variants, (rs145691437, rs3786431, rs201567254, rs3745051 and rs11662259) and one rare missense mutation (c.1922A>G). SNP- and haplotype-based analyses showed no association of these SNPs with schizophrenia. | Genetic analysis of the DLGAP1 gene as a candidate gene for schizophrenia. Li JM, Lu CL, Cheng MC, Luu SU, Hsu SH, Chen CH. | 08/10/2013 |
The GKAP controls the forces operating on microtubules and play a fundamental role in centrosome positioning and cell polarity. | Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity. Manneville JB, Jehanno M, Etienne-Manneville S., Free PMC Article | 12/11/2010 |
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation. Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S., Free PMC Article | 12/5/2010 |
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesNew genetic associations detected in a host response study to hepatitis B vaccine. Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 04/7/2010 |