| SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. | SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
Perlee S, Kikuchi S, Nakadai T, Masuda T, Ohtsuki S, Matsumoto M, Rahmutulla B, Fukuyo M, Cifani P, Kentsis A, Roeder RG, Kaneda A, Hoshii T., Free PMC Article | 10/11/2023 |
| BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer. | BUBs Are New Biomarkers of Promoting Tumorigenesis and Affecting Prognosis in Breast Cancer.
Wang S, Liu X, Yang M, Yuan D, Ye K, Qu X, Wang X., Free PMC Article | 05/14/2022 |
| Research progress of Bub3 gene in malignant tumors. | Research progress of Bub3 gene in malignant tumors.
Wang C, Cheng D, Pan C, Wang C, Nie Z., Free PMC Article | 05/7/2022 |
| Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response. | Dual-functional significance of ATM-mediated phosphorylation of spindle assembly checkpoint component Bub3 in mitosis and the DNA damage response.
Xiao M, Zhang S, Liu Z, Mo Y, Wang H, Zhao X, Yang X, Boohaker RJ, Chen Y, Han Y, Liu H, Xu B., Free PMC Article | 04/30/2022 |
| miR-664b-3p inhibits colon cell carcinoma via negatively regulating Budding uninhibited by benzimidazole 3. | miR-664b-3p inhibits colon cell carcinoma via negatively regulating Budding uninhibited by benzimidazole 3.
Zhao LY, Xin GJ, Tang YY, Li XF, Li YZ, Tang N, Ma YH., Free PMC Article | 04/16/2022 |
| The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia. | The genes for sensory perception of sound should be considered in gene diagnosis of congenital sensorineural hearing loss and microtia.
Lin K, You DY, Zhang LH, Zhou LJ, Zu JY, Xiao Y, Sun MH, Dong-Su, Cao X, Zhang TS, Ma J. | 04/16/2022 |
| Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma. | Expression and prognosis analyses of BUB1, BUB1B and BUB3 in human sarcoma.
Long Z, Wu T, Tian Q, Carlson LA, Wang W, Wu G., Free PMC Article | 07/31/2021 |
| [Expression and clinical significance of Spindly and Bub3 in oral squamous cell carcinoma]. | [Expression and clinical significance of Spindly and Bub3 in oral squamous cell carcinoma].
Zheng J, Li TK, Bao Y, Zhang SX. | 02/13/2021 |
| During mitosis, CRL4 dissociates from RepID and replaces it with RB Binding Protein 7 (RBBP7), which ubiquitinates the SAC mediator BUB3 to enable mitotic exit. | The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.
Jang SM, Nathans JF, Fu H, Redon CE, Jenkins LM, Thakur BL, Pongor LS, Baris AM, Gross JM, OʹNeill MJ, Indig FE, Cappell SD, Aladjem MI., Free PMC Article | 04/25/2020 |
| Findings reveal a regulatory role of Bub3 in DMAP1-mediated DNA methylation upon mitotic stress. | C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer.
Li J, Hu B, Wang T, Huang W, Ma C, Zhao Q, Zhuo L, Zhang T, Jiang Y., Free PMC Article | 06/8/2019 |
| The roles for the BUB3-BUB1 complex in S phase. | The BUB3-BUB1 Complex Promotes Telomere DNA Replication.
Li F, Kim H, Ji Z, Zhang T, Chen B, Ge Y, Hu Y, Feng X, Han X, Xu H, Zhang Y, Yu H, Liu D, Ma W, Songyang Z., Free PMC Article | 01/26/2019 |
| Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade. | BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.
Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A., Free PMC Article | 08/4/2018 |
| The integrity of the mitotic checkpoint complex depends on the specific recognition between BubR1 and Bub3, for which the BubR1 Gle2 binding sequence motif is essential. | Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.
Prinz F, Puetter V, Holton SJ, Andres D, Stegmann CM, Kwiatkowski D, Prechtl S, Petersen K, Beckmann G, Kreft B, Mumberg D, Fernández-Montalván A., Free PMC Article | 12/17/2016 |
| We show that kinetochore recruitment of BUBR1 and BUB3 by BUB1 is dispensable for SAC activation | Dissecting the roles of human BUB1 in the spindle assembly checkpoint.
Vleugel M, Hoek TA, Tromer E, Sliedrecht T, Groenewold V, Omerzu M, Kops GJ. | 06/4/2016 |
| a mutual antagonism exists between Bub3 and dynein to ensure optimal KT-MT attachments | Co-silencing of human Bub3 and dynein highlights an antagonistic relationship in regulating kinetochore-microtubule attachments.
Silva PM, Tavares ÁA, Bousbaa H. | 03/5/2016 |
| the mechanisms of BUB3 in mitotic checkpoint signaling | A motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.
Zhu S, Jing R, Yang Y, Huang Y, Wang X, Leng Y, Xi J, Wang G, Jia W, Kang J., Free PMC Article | 07/25/2015 |
| Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1/BUB3 interaction. | Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.
Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SMA, Kops GJPL. | 06/20/2015 |
| Data indicate that cell cycle protein Bub3-mediated kinetochore recruitment of BubR1 kinase enhances mitotic checkpoint signaling. | Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling.
Han JS, Vitre B, Fachinetti D, Cleveland DW., Free PMC Article | 05/2/2015 |
| Results suggest that these USP7-dependent effects are mediated by decreased levels of spindle assembly checkpoint (SAC) component Bub3. | Usp7 protects genomic stability by regulating Bub3.
Giovinazzi S, Sirleto P, Aksenova V, Morozov VM, Zori R, Reinhold WC, Ishov AM., Free PMC Article | 04/25/2015 |
| Mutations targeting the Bub3 interface prevent kinetochore recruitment of the SAC kinase Bub1. Crucially, they also cause a checkpoint defect, showing that recognition of phosphorylated targets by Bub3 is required for checkpoint signaling | Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.
Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A, Musacchio A., Free PMC Article | 04/4/2015 |
| Results showed that neither variants in BUB3 nor variants in MAD2L1 caused any significant effect on the risk of breast cancer | Genetic variation in the major mitotic checkpoint genes and risk of breast cancer: a multigenic study on cancer susceptibility.
Wang P, Wang Y, Yan H, Xie Q, Zhao L, Xu S, Zhao Q. | 10/11/2014 |
| Mutations in BUB1 and BUB3 cause mosaic variegated aneuploidy and increase the risk of colorectal cancer at a young age. | Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are risk factors for colorectal cancer.
de Voer RM, Geurts van Kessel A, Weren RD, Ligtenberg MJ, Smeets D, Fu L, Vreede L, Kamping EJ, Verwiel ET, Hahn MM, Ariaans M, Spruijt L, van Essen T, Houge G, Schackert HK, Sheng JQ, Venselaar H, van Ravenswaaij-Arts CM, van Krieken JH, Hoogerbrugge N, Kuiper RP. | 11/16/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ., Free PMC Article | 12/5/2010 |
| Results suggest a novel molecular mechanism leading to aneuploidy involving interference of TAp73alpha with Bub1 and Bub3 resulting in an altered mitotic checkpoint. | TAp73alpha binds the kinetochore proteins Bub1 and Bub3 resulting in polyploidy.
Vernole P, Neale MH, Barcaroli D, Munarriz E, Knight RA, Tomasini R, Mak TW, Melino G, De Laurenzi V. | 01/21/2010 |
| Using RNA interference and high-resolution microscopy, we analyzed kinetochore-microtubule attachments in Bub3-depleted cells and compared them to those in Bub1- or BubR1-depleted cells. | The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.
Logarinho E, Resende T, Torres C, Bousbaa H., Free PMC Article | 01/21/2010 |