| Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients. | Integrative multiomics and in silico analysis revealed the role of ARHGEF1 and its screened antagonist in mild and severe COVID-19 patients.
Jha P, Singh P, Arora S, Sultan A, Nayek A, Ponnusamy K, Syed MA, Dohare R, Chopra M., Free PMC Article | 04/16/2022 |
| Identification of Rho GEF and RhoA Activation by Pull-Down Assays. | Identification of Rho GEF and RhoA Activation by Pull-Down Assays.
Sajib MS, Zahra FT, Akwii RG, Mikelis CM. | 03/28/2021 |
| High ARHGEF1 expression is associated with asthmatic airway hyper-responsiveness. | Transforming growth factor-β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.
Shaifta Y, MacKay CE, Irechukwu N, O'Brien KA, Wright DB, Ward JPT, Knock GA., Free PMC Article | 03/30/2019 |
| Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac family small GTPase 1; CCL2 = C-C motif chemokine ligand 2) | p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation.
Singh NK, Janjanam J, Rao GN., Free PMC Article | 09/16/2017 |
| Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. | Structural basis of PDZ-mediated chemokine receptor CXCR2 scaffolding by guanine nucleotide exchange factor PDZ-RhoGEF.
Spellmon N, Holcomb J, Niu A, Choudhary V, Sun X, Zhang Y, Wan J, Doughan M, Hayden S, Hachem F, Brunzelle J, Li C, Yang Z., Free PMC Article | 06/24/2017 |
| We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 | Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
Croisé P, Houy S, Gand M, Lanoix J, Calco V, Tóth P, Brunaud L, Lomazzi S, Paramithiotis E, Chelsky D, Ory S, Gasman S. | 01/28/2017 |
| contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF | [Under hypoxia condition contactin-1 regulates migration of MKN45 cells through RhoA pathway].
Yang G, Song JG, Li Y, Gong SP. | 05/30/2015 |
| The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF signaling module. | A novel role for p115RhoGEF in regulation of epithelial plasticity.
Kher SS, Struckhoff AP, Alberts AS, Worthylake RA., Free PMC Article | 11/22/2014 |
| Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs). | Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs).
Carter AM, Gutowski S, Sternweis PC., Free PMC Article | 10/4/2014 |
| Modification of p115RhoGEF at Serine(330) regulates its RhoGEF activity. | Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity.
Chow CR, Suzuki N, Kawamura T, Hamakubo T, Kozasa T., Free PMC Article | 03/22/2014 |
| The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. | Prenylation and membrane localization of Cdc42 are essential for activation by DOCK7.
Zhou Y, Johnson JL, Cerione RA, Erickson JW., Free PMC Article | 08/31/2013 |
| High GEF1 expression is associated with metastasis of pancreatic cancer. | miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
Hu Y, Ou Y, Wu K, Chen Y, Sun W. | 02/2/2013 |
| Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. | Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domain.
Chen Z, Guo L, Hadas J, Gutowski S, Sprang SR, Sternweis PC., Free PMC Article | 10/20/2012 |
| Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers. | Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA.
Ma X, Zhao Y, Daaka Y, Nie Z., Free PMC Article | 08/25/2012 |
| Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. | Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule.
Hartney JM, Gustafson CE, Bowler RP, Pelanda R, Torres RM., Free PMC Article | 03/3/2012 |
| Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). | Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).
Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR., Free PMC Article | 07/30/2011 |
| The linker region connecting the N-terminal RGS-homology domain and the Dbl homology domain inhibits the intrinsic guanine nucleotide exchange activity of p115. | Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.
Chen Z, Guo L, Sprang SR, Sternweis PC., Free PMC Article | 04/16/2011 |
| ARHGEF1 is involed in hypertension by controlling its molecular mechanisms. | [The exchange factor Arhgef1: a new target in hypertension].
Loirand G, Pacaud P. | 09/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K. | 01/20/2010 |
| Data show that microtubules in neighboring cells reorient and target p115 RhoGEF to sites where dying cells are squeezed out of the epithelial sheet. | P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium.
Slattum G, McGee KM, Rosenblatt J., Free PMC Article | 01/21/2010 |
| A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. | Reversible translocation of p115-RhoGEF by G(12/13)-coupled receptors.
Meyer BH, Freuler F, Guerini D, Siehler S. | 01/21/2010 |
| analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway | Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization.
Shumay E, Tao J, Wang HY, Malbon CC. | 01/21/2010 |
| CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression | Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
Bourguignon LY, Singleton PA, Zhu H, Diedrich F. | 01/21/2010 |
| coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation | B plexins activate Rho through PDZ-RhoGEF.
Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG. | 01/21/2010 |