| Introduction to DOK2 and its potential role in cancer. | Introduction to DOK2 and its potential role in cancer.
Sun P, Li R, Meng Y, Xi S, Wang Q, Yang X, Peng X, Cai J., Free PMC Article | 03/12/2022 |
| Decreased DOK1/2 expressions associated with their promoter hypermethylations predict adverse prognosis in AML. | Methylation-associated DOK1 and DOK2 down-regulation: Potential biomarkers for predicting adverse prognosis in acute myeloid leukemia.
He PF, Xu ZJ, Zhou JD, Li XX, Zhang W, Wu DH, Zhang ZH, Lian XY, Yao XY, Deng ZQ, Lin J, Qian J. | 09/21/2019 |
| DOK2 overexpression in different brain regions is associated with poor prognosis in astrocytoma clinical cases. | Region-Specific Dok2 Overexpression Associates with Poor Prognosis in Human Astrocytoma.
Deshpande RP, Chandra Sekhar YBVK, Panigrahi M, Babu PP. | 03/16/2019 |
| In this report, the authors demonstrated that the cellular adaptor proteins Dok-2 and Dok-1 are tyrosine phosphorylated upon herpes simplex virus 1 infection. In addition, herpes simplex virus 1 induced the selective degradation of Dok-2. Finally, Dok-2 interacts with herpes simplex virus 1 VP11/12, and that herpes simplex virus 1-induced tyrosine phosphorylation and degradation of Dok-2 require VP11/12. | Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2.
Lahmidi S, Strunk U, Smiley JR, Pearson A, Duplay P. | 10/14/2017 |
| DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. | Expression of DOK1, 2, and 3 genes in HTLV-1-infected T cells.
Ohsugi T, Wakamiya M, Morikawa S, Fujita M. | 09/24/2016 |
| point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB domain | Mutational analysis of the DOK2 haploinsufficient tumor suppressor gene in chronic myelomonocytic leukemia (CMML).
Coppin E, Gelsi-Boyer V, Morelli X, Cervera N, Murati A, Pandolfi PP, Birnbaum D, Nunès JA. | 04/11/2015 |
| Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of natural killer-cell-activating receptors in mouse and human. | Dok1 and Dok2 proteins regulate natural killer cell development and function.
Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, Dalod M, Vivier E, Nunès JA., Free PMC Article | 11/8/2014 |
| DOK2 as a tumor suppressor in EGFR-mutant lung adenocarcinoma | DOK2 inhibits EGFR-mutated lung adenocarcinoma.
Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP., Free PMC Article | 09/6/2014 |
| DOK2 is a marker of poor prognosis in patients with gastric cancer after curative resection | DOK2 as a marker of poor prognosis of patients with gastric adenocarcinoma after curative resection.
Miyagaki H, Yamasaki M, Takahashi T, Kurokawa Y, Miyata H, Nakajima K, Takiguchi S, Fujiwara Y, Mori M, Doki Y. | 09/29/2012 |
| Data indicate there was no evidence of DOK2 somatic mutation in the leukemias analyzed. | Mutational analysis of DOK2 tumor suppressor gene in acute leukemias.
Kim MS, Chung NG, Yoo NJ, Lee SH. | 12/10/2011 |
| data indicate that DOK2 is altered in gastric (GC) and colorectal cancers (CRC) by loss of expressions; data indicate that somatic mutation of DOK2 may be rare in GC, CRC, breast cancer, prostate cancer and liver cancer | Mutational and expressional analysis of a haploinsufficient tumor suppressor gene DOK2 in gastric and colorectal cancers.
An CH, Kim MS, Yoo NJ, Lee SH. | 11/5/2011 |
| Dok1 negatively regulates Dok2-mediated CD200R signaling through the recruitment of CrkL. | Downstream of tyrosine kinase 1 and 2 play opposing roles in CD200 receptor signaling.
Mihrshahi R, Brown MH., Free PMC Article | 01/8/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Identification of DOK genes as lung tumor suppressors. | Identification of DOK genes as lung tumor suppressors.
Berger AH, Niki M, Morotti A, Taylor BS, Socci ND, Viale A, Brennan C, Szoke J, Motoi N, Rothman PB, Teruya-Feldstein J, Gerald WL, Ladanyi M, Pandolfi PP., Free PMC Article | 04/19/2010 |
| CD200R inhibits the activation of human myeloid cells through direct recruitment of Dok2 and subsequent activation of RAS p21 protein activator 1. | Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells.
Mihrshahi R, Barclay AN, Brown MH., Free PMC Article | 01/21/2010 |
| Dok-1/Dok-2 pleckstrin homology domains bind in vitro to the rare phosphoinositide species, phosphatidylinositol 5-phosphate | Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.
Guittard G, Gérard A, Dupuis-Coronas S, Tronchère H, Mortier E, Favre C, Olive D, Zimmermann P, Payrastre B, Nunès JA. | 01/21/2010 |
| The data provide evidence that DOK2 protein has a role in regulating cell proliferation and differentiation and is positive regulators of the MAPK signaling pathway in this context. | All-trans retinoic acid induces p62DOK1 and p56DOK2 expression which enhances induced differentiation and G0 arrest of HL-60 leukemia cells.
Lamkin TJ, Chin V, Yen A. | 01/21/2010 |
| Dok-R acts as an EGFR-recruited scaffolding molecule that processively assembles c-Src and Csk to attenuate signaling from the EGFR. | Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk.
Van Slyke P, Coll ML, Master Z, Kim H, Filmus J, Dumont DJ., Free PMC Article | 01/21/2010 |
| Dok-2 tyrosine phosphorylation was also found to be involved in collagen receptor, glycoprotein VI (GPVI), signaling as well as in outside-in signaling through the major platelet integrin, alpha IIIb beta 3 | Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.
García A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N. | 01/21/2010 |
| Phosphotyrosine-binding mediated oligomerization of Dok-1 and Dok-2 represents an essential step for Dok phosphorylation and function. | Phosphotyrosine binding-mediated oligomerization of downstream of tyrosine kinase (Dok)-1 and Dok-2 is involved in CD2-induced Dok phosphorylation.
Boulay I, Némorin JG, Duplay P. | 01/21/2010 |
| Dok-R and c-Abl interact in both a constitutive and inducible fashion and Dok-R influences the intracellular kinase and biological activity of c-Abl | Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization.
Master Z, Tran J, Bishnoi A, Chen SH, Ebos JM, Van Slyke P, Kerbel RS, Dumont DJ. | 01/21/2010 |
| Dok-2 is a critical element of a linker for activation of T cells (LAT)-dependent negative feedback loop that attenuates early T-cell receptor (TCR) signal. | T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.
Dong S, Corre B, Foulon E, Dufour E, Veillette A, Acuto O, Michel F., Free PMC Article | 01/21/2010 |
| identified tyrosine residue 1106 on Tie2 as an Angiopoietin 1-dependent autophosphorylation site that mediates binding and phosphorylation of the downstream-of-kinase-related (Dok-R) docking protein | A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.
Jones N, Chen SH, Sturk C, Master Z, Tran J, Kerbel RS, Dumont DJ., Free PMC Article | 01/21/2010 |
| DOK1 and DOK2 interact with the Tec protein tyrosine kinase. | Functional interaction of RasGAP-binding proteins Dok-1 and Dok-2 with the Tec protein tyrosine kinase.
Gérard A, Favre C, Garçon F, Némorin JG, Duplay P, Pastor S, Collette Y, Olive D, Nunès JA. | 01/21/2010 |