| The human-specific nicotinic receptor subunit CHRFAM7A reduces alpha7 receptor function in human induced pluripotent stem cells-derived and transgenic mouse neurons. | The human-specific nicotinic receptor subunit CHRFAM7A reduces α7 receptor function in human induced pluripotent stem cells-derived and transgenic mouse neurons.
Görgülü I, Jagannath V, Pons S, Koniuszewski F, Groszer M, Maskos U, Huck S, Scholze P. | 09/13/2024 |
| CHRFAM7A diversifies human immune adaption through Ca[2+] signalling and actin cytoskeleton reorganization. | CHRFAM7A diversifies human immune adaption through Ca(2+) signalling and actin cytoskeleton reorganization.
Szigeti K, Ihnatovych I, Notari E, Dorn RP, Maly I, He M, Birkaya B, Prasad S, Byrne RS, Indurthi DC, Nimmer E, Heo Y, Retfalvi K, Chaves L, Sule N, Hofmann WA, Auerbach A, Wilding G, Bae Y, Reynolds J., Free PMC Article | 08/7/2024 |
| Unraveling the molecular interactions between alpha7 nicotinic receptor and a RIC3 variant associated with backward speech. | Unraveling the molecular interactions between α7 nicotinic receptor and a RIC3 variant associated with backward speech.
Pradhan A, Mounford H, Peixinho J, Rea E, Epeslidou E, Scott JS, Cull J, Maxwell S, Webster R, Beeson D, Dong YY, Prekovic S, Bermudez I, Newbury DF., Free PMC Article | 03/15/2024 |
| Structural mechanisms of alpha7 nicotinic receptor allosteric modulation and activation. | Structural mechanisms of α7 nicotinic receptor allosteric modulation and activation.
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE., | 03/8/2024 |
| Human-specific CHRFAM7A primes macrophages for a heightened pro-inflammatory response at the earlier stage of inflammation. | Human-specific CHRFAM7A primes macrophages for a heightened pro-inflammatory response at the earlier stage of inflammation.
Zhou R, Niu K, Wang C, He J, Huang W, Li T, Lan H, Zhang Y, Dang X, Mao L. | 11/20/2023 |
| An original potentiating mechanism revealed by the cryo-EM structures of the human alpha7 nicotinic receptor in complex with nanobodies. | An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Prevost MS, Barilone N, Dejean de la Bâtie G, Pons S, Ayme G, England P, Gielen M, Bontems F, Pehau-Arnaudet G, Maskos U, Lafaye P, Corringer PJ., Free PMC Article | 09/29/2023 |
| Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours. | Human-specific duplicate CHRFAM7A gene is associated with more severe osteoarthritis and amplifies pain behaviours.
Courties A, Olmer M, Myers K, Ordoukhanian P, Head SR, Natarajan P, Berenbaum F, Sellam J, Lotz MK., Free PMC Article | 04/14/2023 |
| Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy. | Up-regulation of the human-specific CHRFAM7A gene protects against renal fibrosis in mice with obstructive nephropathy.
Zhou B, Zhang Y, Dang X, Li B, Wang H, Gong S, Li S, Meng F, Xing J, Li T, He L, Zou P, Wan Y., Free PMC Article | 01/7/2023 |
| The Human-Restricted Isoform of the alpha7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders. | The Human-Restricted Isoform of the α7 nAChR, CHRFAM7A: A Double-Edged Sword in Neurological and Inflammatory Disorders.
Di Lascio S, Fornasari D, Benfante R., Free PMC Article | 04/30/2022 |
| CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway. | CHRFAM7A Overexpression Attenuates Cerebral Ischemia-Reperfusion Injury via Inhibiting Microglia Pyroptosis Mediated by the NLRP3/Caspase-1 pathway.
Cao X, Wang Y, Gao L. | 12/11/2021 |
| Effect of CHRFAM7A Delta2bp gene variant on secondary inflammation after spinal cord injury. | Effect of CHRFAM7A Δ2bp gene variant on secondary inflammation after spinal cord injury.
Lin M, Huang W, Kabbani N, Theiss MM, Hamilton JF, Ecklund JM, Conley YP, Vodovotz Y, Brienza D, Wagner AK, Robbins E, Sowa GA, Lipsky RH., Free PMC Article | 10/23/2021 |
| The human-specific duplicated alpha7 gene inhibits the ancestral alpha7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release. | The human-specific duplicated α7 gene inhibits the ancestral α7, negatively regulating nicotinic acetylcholine receptor-mediated transmitter release.
Martín-Sánchez C, Alés E, Balseiro-Gómez S, Atienza G, Arnalich F, Bordas A, Cedillo JL, Extremera M, Chávez-Reyes A, Montiel C., Free PMC Article | 08/28/2021 |
| Regulation of the acetylcholine/alpha7nAChR anti-inflammatory pathway in COVID-19 patients. | Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.
Courties A, Boussier J, Hadjadj J, Yatim N, Barnabei L, Péré H, Veyer D, Kernéis S, Carlier N, Pène F, Rieux-Laucat F, Charbit B, Bondet V, Duffy D, Berenbaum F, Terrier B, Sellam J., Free PMC Article | 06/19/2021 |
| Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupalpha7) Nicotinic Receptor Linked to Neuropsychiatric Disorders. | Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupα7) Nicotinic Receptor Linked to Neuropsychiatric Disorders.
Liu D, de Souza JV, Ahmad A, Bronowska AK., Free PMC Article | 06/19/2021 |
| Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. | Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.
Benfante R, Di Lascio S, Cardani S, Fornasari D. | 05/8/2021 |
| Human-specific gene CHRFAM7A mediates M2 macrophage polarization via the Notch pathway to ameliorate hypertrophic scar formation. | Human-specific gene CHRFAM7A mediates M2 macrophage polarization via the Notch pathway to ameliorate hypertrophic scar formation.
Li T, Chen W, Zhang Q, Deng C. | 02/20/2021 |
| Association of a Functional Polymorphism in the CHRFAM7A Gene with Inflammatory Response Mediators and Neuropathic Pain after Spinal Cord Injury. | Association of a Functional Polymorphism in the CHRFAM7A Gene with Inflammatory Response Mediators and Neuropathic Pain after Spinal Cord Injury.
Huang W, Kabbani N, Brannan TK, Lin MK, Theiss MM, Hamilton JF, Ecklund JM, Conley YP, Vodovotz Y, Brienza D, Wagner AK, Robbins E, Sowa GA, Lipsky RH. | 11/21/2020 |
| CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro. | CHRFAM7A reduces monocyte/macrophage migration and colony formation in vitro.
Chan TW, Langness S, Cohen O, Eliceiri BP, Baird A, Costantini TW., Free PMC Article | 10/10/2020 |
| The analysis of the CHRFAM7A gene's regulatory region reveals some of the mechanisms driving its expression and responsiveness to LPS in human immune cell models. donepezil differently modulates CHRFAM7A responsiveness to LPS. | Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway.
Maroli A, Di Lascio S, Drufuca L, Cardani S, Setten E, Locati M, Fornasari D, Benfante R. | 04/4/2020 |
| Our study observations support the role for CHRFAM7A gene in schizophrenia pathogenesis and suggest a potential novel link between deficient CHRFAM7A expression and negative psychopathology | CHRFAM7A gene expression in schizophrenia: clinical correlates and the effect of antipsychotic treatment.
Kalmady SV, Agrawal R, Venugopal D, Shivakumar V, Amaresha AC, Agarwal SM, Subbanna M, Rajasekaran A, Narayanaswamy JC, Debnath M, Venkatasubramanian G. | 10/5/2019 |
| The CHRFAM7A gene contributes to the pathogenesis of neuropsychiatric disorders. | Global proteomic profiling of the uniquely human CHRFAM7A gene in transgenic mouse brain.
Jiang Y, Yuan H, Huang L, Hou X, Zhou R, Dang X. | 08/24/2019 |
| Study suggests a negative modulatory effect of CHRFAM7A on synaptic transmission (relevance in schizophrenia) and a modulatory effect on Abeta1-42 uptake (relevance to Alzheimer disease). | iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context.
Ihnatovych I, Nayak TK, Ouf A, Sule N, Birkaya B, Chaves L, Auerbach A, Szigeti K., Free PMC Article | 06/15/2019 |
| Genetic variation CHRFAM7A is associated with nicotine dependence and response to varenicline treatment. | Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.
Cameli C, Bacchelli E, De Paola M, Giucastro G, Cifiello S, Collo G, Cainazzo MM, Pini LA, Maestrini E, Zoli M., Free PMC Article | 03/30/2019 |
| gp120IIIB promotes the downregulation of CHRFAM7A in neuronal cells. | Expression of CHRFAM7A and CHRNA7 in neuronal cells and postmortem brain of HIV-infected patients: considerations for HIV-associated neurocognitive disorder.
Ramos FM, Delgado-Vélez M, Ortiz ÁL, Báez-Pagán CA, Quesada O, Lasalde-Dominicci JA., Free PMC Article | 01/27/2018 |
| Data show preferential fetal CHRFAM7A expression in the human prefrontal cortex and suggest abnormalities in the CHRFAM7A/CHRNA7 ratios in schizophrenia and bipolar disorder, due mainly to overexpression of CHRFAM7A. | CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.
Kunii Y, Zhang W, Xu Q, Hyde TM, McFadden W, Shin JH, Deep-Soboslay A, Ye T, Li C, Kleinman JE, Wang KH, Lipska BK. | 03/12/2016 |