| SYNJ2 is a novel and potential biomarker for the prediction and treatment of cancers: from lung squamous cell carcinoma to pan-cancer. | SYNJ2 is a novel and potential biomarker for the prediction and treatment of cancers: from lung squamous cell carcinoma to pan-cancer.
Hou W, Li GS, Gao L, Lu HP, Zhou HF, Kong JL, Chen G, Xia S, Wei HY., Free PMC Article | 05/28/2022 |
| Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma. | Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma.
Zhang R, Mo WJ, Huang LS, Chen JT, Wu WZ, He WY, Feng ZB., Free PMC Article | 11/22/2021 |
| Results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population. | SYNJ2 variant rs9365723 is associated with colorectal cancer risk in Chinese Han population.
Du Q, Guo X, Zhang X, Zhou W, Liu Z, Wang J, Zhang T, Mao Z, Luo J, Jin T, Liu C. | 04/8/2017 |
| Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer. | Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.
Ben-Chetrit N, Chetrit D, Russell R, Körner C, Mancini M, Abdul-Hai A, Itkin T, Carvalho S, Cohen-Dvashi H, Koestler WJ, Shukla K, Lindzen M, Kedmi M, Lauriola M, Shulman Z, Barr H, Seger D, Ferraro DA, Pareja F, Gil-Henn H, Lapidot T, Alon R, Milanezi F, Symons M, Ben-Hamo R, Efroni S, Schmitt F, Wiemann S, Caldas C, Ehrlich M, Yarden Y. | 01/16/2016 |
| The genetic interactions associated with ILVatrophy rate in this study may be mapping variants inSYNJ2andPI4KAthat interact to decrease synthesisof PIP. | Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size.
Koran ME, Hohman TJ, Meda SA, Thornton-Wells TA., Free PMC Article | 06/21/2014 |
| Src-mediated phosphorylation of SYNJ2 contributes to invadopodia formation. | Regulation of synaptojanin 2 5'-phosphatase activity by Src.
Chuang Y, Xu X, Kwiatkowska A, Tsapraillis G, Hwang H, Petritis K, Flynn D, Symons M., Free PMC Article | 06/15/2013 |
| SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities. | Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts.
Lopez LM, Harris SE, Luciano M, Liewald D, Davies G, Gow AJ, Tenesa A, Payton A, Ke X, Whalley LJ, Fox H, Haggerty P, Ollier W, Pickles A, Porteous DJ, Horan MA, Pendleton N, Starr JM, Deary IJ., Free PMC Article | 06/16/2012 |
| Single nucleotide polymorphisms in SYNJ2 are associated with personality disorders. | Longevity candidate genes and their association with personality traits in the elderly.
Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A, Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ., Free PMC Article | 05/26/2012 |
| SYNJ2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. | The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML., Free PMC Article | 09/14/2011 |
| Since Syn 2 is a phosphatidylinositol 4,5-biphosphatase involved in cell growth and rearrangement of actin filaments, the increased Syn 2 expression may correlate with the hairy cell leukemia etiology or the characteristic morphologic alterations. | Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells.
Spaenij-Dekking EH, Van Delft J, Van Der Meijden E, Hiemstra HS, Falkenburg JH, Koning F, Drijfhout JW, Kluin-Nelemans JC. | 01/21/2010 |
| contributes to the role of Rac1 in cell invasion and migration by regulating the formation of invadopodia and lamellipodia | Role of synaptojanin 2 in glioma cell migration and invasion.
Chuang YY, Tran NL, Rusk N, Nakada M, Berens ME, Symons M. | 01/21/2010 |
| Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells | Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.
Rossi MR, Hawthorn L, Platt J, Burkhardt T, Cowell JK, Ionov Y. | 01/21/2010 |