| PPARgamma dependent PEX11beta counteracts the suppressive role of SIRT1 on neural differentiation of HESCs. | PPARgamma dependent PEX11beta counteracts the suppressive role of SIRT1 on neural differentiation of HESCs.
Esmaeili M, Nasr-Esfahani MH, Shoaraye Nejati A, Safaeinejad Z, Atefi A, L Megraw T, Ghaedi K., Free PMC Article | 06/13/2024 |
| Two siblings with PEX11B-related peroxisome biogenesis disorder. | Two siblings with PEX11B-related peroxisome biogenesis disorder.
Khoddam S, Kamal N, Shiri A, Jafari Khamirani H, Manoochehri J, Dianatpour M, Tabei SMB, Dastgheib SA. | 03/20/2024 |
| Genetic defects in peroxisome morphogenesis (Pex11beta, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism. | Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism.
Abe Y, Wanders RJA, Waterham HR, Mandel H, Falik-Zaccai TC, Ishihara N, Fujiki Y. | 03/20/2023 |
| PEX11beta and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. | PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor.
Schrader TA, Carmichael RE, Islinger M, Costello JL, Hacker C, Bonekamp NA, Weishaupt JH, Andersen PM, Schrader M., Free PMC Article | 07/16/2022 |
| Authors provide evidence that PXMP2 is not essential for H2O2 permeation across the peroxisomal membrane, neither in control cells nor in cells lacking PEX11B, a peroxisomal membrane-shaping protein whose yeast homologue facilitates the permeation of molecules up to 400Da. | Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting.
Lismont C, Koster J, Provost S, Baes M, Van Veldhoven PP, Waterham HR, Fransen M. | 04/4/2020 |
| Next generation sequencing identified biallelic loss-of-function mutations in PEX11B as the underlying cause of disease in each case (PEX11B c.235C>T p.(Arg79Ter) homozygous; PEX11B c.136C>T p.(Arg46Ter) homozygous; PEX11B c.595C>T p.(Arg199Ter) heterozygous, PEX11B ex1-3 del heterozygous). | Novel PEX11B Mutations Extend the Peroxisome Biogenesis Disorder 14B Phenotypic Spectrum and Underscore Congenital Cataract as an Early Feature.
Taylor RL, Handley MT, Waller S, Campbell C, Urquhart J, Meynert AM, Ellingford JM, Donnelly D, Wilcox G, Lloyd IC, Mundy H, FitzPatrick DR, Deshpande C, Clayton-Smith J, Black GC., Free PMC Article | 06/24/2017 |
| Self-interaction of human Pex11beta during peroxisomal growth and division regulates its membrane deforming activity in conjunction with membrane lipids. | Self-interaction of human Pex11pβ during peroxisomal growth and division.
Bonekamp NA, Grille S, Cardoso MJ, Almeida M, Aroso M, Gomes S, Magalhaes AC, Ribeiro D, Islinger M, Schrader M., Free PMC Article | 07/6/2013 |
| A new study identifies the first patient with a mutation in PEX11beta.These new findings widen the spectrum of clinical and cellular phenotypes of peroxisome biogenesis disorders. | First PEX11β patient extends spectrum of peroxisomal biogenesis disorder phenotypes.
Thoms S, Gärtner J. | 11/24/2012 |
| Excluding mutations in all PEX genes previously implicated in peroxisome biogenesis disorders, it was found that the defect was caused by a homozygous non-sense mutation in the PEX11beta gene. | A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11β gene.
Ebberink MS, Koster J, Visser G, Spronsen Fv, Stolte-Dijkstra I, Smit GP, Fock JM, Kemp S, Wanders RJ, Waterham HR. | 11/24/2012 |
| coordinates peroxisome membrane proliferation and maintenance | PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance.
Koch J, Pranjic K, Huber A, Ellinger A, Hartig A, Kragler F, Brocard C. | 05/14/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1. | Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis.
Kobayashi S, Tanaka A, Fujiki Y. | 01/21/2010 |