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    TNFSF14 TNF superfamily member 14 [ Homo sapiens (human) ]

    Gene ID: 8740, updated on 4-Jan-2025

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study.

    TNFSF14 mediates the impact of docosahexaenoic acid on atopic dermatitis: a Mendelian randomization study.
    Huang XW, Pang SW, Yang LZ, Han T, Chen JM, Huang CW, Liao L, Xie PJ.

    02/7/2024
    Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.

    Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis.
    Kanai S, Fujiwara H, Mizuno S, Kishikawa T, Nakatsuka T, Hamada T, Tanaka M, Arita J, Nakai Y, Isayama H, Kasuga M, Tateishi R, Tateishi K, Ushiku T, Hasegawa K, Koike K, Fujishiro M.

    02/1/2024
    LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment.

    LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity through reversing immunosuppressive tumor microenvironment.
    Zhang N, Liu X, Qin J, Sun Y, Xiong H, Lin B, Liu K, Tan B, Zhang C, Huang C, Ren S, Liu M, Du B., Free PMC Article

    11/2/2023
    LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells.

    LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells.
    Heo SK, Yu HM, Kim DK, Seo HJ, Shin Y, Kim SA, Kim M, Kim Y, Lee YJ, Noh EK, Jo JC., Free PMC Article

    08/10/2023
    High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome.

    High levels of LIGHT/TNFSF14 in patients with Prader-Willi syndrome.
    Faienza MF, Brunetti G, Fintini D, Grugni G, Wasniewska MG, Crinò A, D'Amato G, Piacente L, Oranger A, Dicarlo M, Colucci S, Grano M., Free PMC Article

    07/31/2023
    A LIGHT-HVEM/LTbetaR axis contributes to the fibrosis of intrauterine adhesion.

    A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion.
    Abudukeyoumu A, Lai ZZ, Lu JJ, Zhang X, Hou DY, Dong J, Wu JN, Li MQ, Xie F.

    10/8/2022
    The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.

    The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.
    Ikawa T, Ichimura Y, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.

    06/11/2022
    LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTbetaR-mediated mechanisms.

    LIGHT controls distinct homeostatic and inflammatory gene expression profiles in esophageal fibroblasts via differential HVEM and LTβR-mediated mechanisms.
    Manresa MC, Wu A, Nhu QM, Chiang AWT, Okamoto K, Miki H, Kurten R, Pham E, Duong LD, Lewis NE, Akuthota P, Croft M, Aceves SS., Free PMC Article

    04/16/2022
    The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps.

    The tumor necrosis factor family molecules LIGHT and lymphotoxins in sinus mucosa of patients with chronic rhinosinusitis with or without nasal polyps.
    Hwang JW, Kim YC, Lee HY, Lee KJ, Kim TH, Lee SH.

    02/19/2022
    Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility.

    Genomic and functional evaluation of TNFSF14 in multiple sclerosis susceptibility.
    Zuccalà M, Barizzone N, Boggio E, Gigliotti L, Sorosina M, Basagni C, Bordoni R, Clarelli F, Anand S, Mangano E, Vecchio D, Corsetti E, Martire S, Perga S, Ferrante D, Gajofatto A, Ivashynka A, Solaro C, Cantello R, Martinelli V, Comi G, Filippi M, Esposito F, Leone M, De Bellis G, Dianzani U, Martinelli-Boneschi F, D'Alfonso S.

    02/5/2022
    HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.

    HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160.
    Liu W, Chou TF, Garrett-Thomson SC, Seo GY, Fedorov E, Ramagopal UA, Bonanno JB, Wang Q, Kim K, Garforth SJ, Kakugawa K, Cheroutre H, Kronenberg M, Almo SC., Free PMC Article

    01/1/2022
    Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles.

    Abundant TNF-LIGHT expression in the airways of patients with asthma with persistent airflow limitation: Association with nitrative and inflammatory profiles.
    Hirano T, Matsunaga K, Oishi K, Doi K, Harada M, Suizu J, Murakawa K, Chikumoto A, Ohteru Y, Matsuda K, Uehara S, Hamada K, Ohata S, Murata Y, Yamaji Y, Asami-Noyama M, Edakuni N.

    10/30/2021
    Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160.

    Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160.
    Shrestha R, Garrett-Thomson SC, Liu W, Almo SC, Fiser A., Free PMC Article

    10/16/2021
    LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients.

    LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients.
    Brunetti G, Belisario DC, Bortolotti S, Storlino G, Colaianni G, Faienza MF, Sanesi L, Alliod V, Buffoni L, Centini E, Voena C, Pulito R, Novello S, Ingravallo G, Rizzi R, Mori G, Reseland JE, Ware CF, Colucci S, Ferracini R, Grano M, Roato I.

    09/18/2021
    LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.

    LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.
    Heo SK, Choi Y, Jeong YK, Ju LJ, Yu HM, Kim DK, Seo HJ, Lee YJ, Cheon J, Koh S, Min YJ, Noh EK, Jo JC., Free PMC Article

    08/28/2021
    TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation.

    TNFSF14, a novel target of miR-326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation.
    Zhang H, Yan HL, Li XY, Guo YN.

    07/17/2021
    The impact of TNFSF14 on prognosis and immune microenvironment in clear cell renal cell carcinoma.

    The impact of TNFSF14 on prognosis and immune microenvironment in clear cell renal cell carcinoma.
    Xu F, Guan Y, Zhang P, Xue L, Yang X, Gao K, Chong T.

    07/10/2021
    Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients.

    Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients.
    Fan H, Lu B, Cao C, Li H, Yang D, Huang L, Ding T, Wu M, Lu G., Free PMC Article

    07/3/2021
    Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage.

    Increased level of LIGHT/TNFSF14 is associated with survival in aneurysmal subarachnoid hemorrhage.
    Schranz D, Molnar T, Erdo-Bonyar S, Simon D, Berki T, Nagy C, Czeiter E, Buki A, Lenzser G, Csecsei P.

    06/5/2021
    LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-kappaB pathway.

    LIGHT aggravates sepsis-associated acute kidney injury via TLR4-MyD88-NF-κB pathway.
    Zhong Y, Wu S, Yang Y, Li GQ, Meng L, Zheng QY, Li Y, Xu GL, Zhang KQ, Peng KF., Free PMC Article

    05/8/2021
    Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis.

    Tumor necrosis factor superfamily 14 is critical for the development of renal fibrosis.
    Li Y, Tang M, Han B, Wu S, Li SJ, He QH, Xu F, Li GQ, Zhang K, Cao X, Zheng QY, Chen J, Yang D, Xu GL, Zhang KQ., Free PMC Article

    04/24/2021
    Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype.

    Increased Production of LIGHT by T Cells in Eosinophilic Esophagitis Promotes Differentiation of Esophageal Fibroblasts Toward an Inflammatory Phenotype.
    Manresa MC, Chiang AWT, Kurten RC, Dohil R, Brickner H, Dohil L, Herro R, Akuthota P, Lewis NE, Croft M, Aceves SS., Free PMC Article

    04/17/2021
    Shedding ""LIGHT"" on the Link between Bone and Fat in Obese Children and Adolescents.

    Shedding "LIGHT" on the Link between Bone and Fat in Obese Children and Adolescents.
    Brunetti G, Faienza MF, Piacente L, Storlino G, Oranger A, D'Amato G, De Filippo G, Colucci S, Grano M., Free PMC Article

    02/27/2021
    LIGHT/LTbetaR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.

    LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
    Höpner SS, Raykova A, Radpour R, Amrein MA, Koller D, Baerlocher GM, Riether C, Ochsenbein AF., Free PMC Article

    02/27/2021
    Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.

    Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.
    Iriyama T, Wang G, Yoshikawa M, Mimura N, Matsui H, Sayama S, Kumasawa K, Nagamatsu T, Koga K, Kotani T, Niimi K, Yamamoto E, Kellems RE, Xia Y, Osuga Y, Fujii T., Free PMC Article

    12/12/2020
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