| The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase. | The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.
Yang YC, Lin YW, Lee WJ, Lai FR, Ho KH, Chu CY, Hua KT, Chen JQ, Tung MC, Hsiao M, Wen YC, Chien MH., Free PMC Article | 08/16/2023 |
| Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner. | Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.
Long F, Li L, Xie C, Ma M, Wu Z, Lu Z, Liu B, Yang M, Zhang F, Ning Z, Zhong C, Yu B, Liu S, Wan L, Tian B, Yang K, Guo Y, Chen M, Chou J, Li X, Hu G, Lin C, Zhang Y., Free PMC Article | 08/16/2023 |
| Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis. | Identification of KHSRP-Regulated RNAs in Esophageal Cancer by Integrated Bioinformatics Analysis.
Chen L, Zhao T. | 12/4/2021 |
| Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation. | Inhibition of KHSRP sensitizes colorectal cancer to 5-fluoruracil through miR-501-5p-mediated ERRFI1 mRNA degradation.
Pan R, Cai W, Sun J, Yu C, Li P, Zheng M. | 10/24/2020 |
| In NSCLC cell lines, overexpression of HNRNPC significantly promoted lung cancer cell proliferation, migration, and invasion in vitro and in vivo. KHSRP and HNRNPC may induce human lung cancer cell invasion and metastasis by activating the IFN-alpha-JAK-STAT1 signaling pathway. | RNA-binding protein KHSRP promotes tumor growth and metastasis in non-small cell lung cancer.
Yan M, Sun L, Li J, Yu H, Lin H, Yu T, Zhao F, Zhu M, Liu L, Geng Q, Kong H, Pan H, Yao M., Free PMC Article | 06/6/2020 |
| High KHSRP expression is associated with Colorectal Cancer Cell Growth. | KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.
Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ., Free PMC Article | 03/28/2020 |
| This is the first report demonstrating that KSRP is involved in the regulation of T cell responses. We present strong evidence that T cells derived from KSRP(-/-) mice favor Th2-driven immune responses. | The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4(+) T Cells.
Käfer R, Schmidtke L, Schrick K, Montermann E, Bros M, Kleinert H, Pautz A., Free PMC Article | 02/15/2020 |
| Results show that KSRP expression is significantly up-regulated in human melanoma. It modulates melanoma cell growth by repressing the expression of KLLN through mRNA decay and interaction with the AU-rich elements in the 3' UTR. | KSRP modulates melanoma growth and efficacy of vemurafenib.
Liu W, Chou CF, Liu S, Crossman D, Yusuf N, Wu Y, Chen CY., Free PMC Article | 11/30/2019 |
| The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally. | The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
Schmidtke L, Schrick K, Saurin S, Käfer R, Gather F, Weinmann-Menke J, Kleinert H, Pautz A. | 09/7/2019 |
| Decreased expression of KHSRP, thus increasing CDKN1a (p21) expression. | Long Noncoding RNA AB074169 Inhibits Cell Proliferation via Modulation of KHSRP-Mediated CDKN1a Expression in Papillary Thyroid Carcinoma.
Gou Q, Gao L, Nie X, Pu W, Zhu J, Wang Y, Liu X, Tan S, Zhou JK, Gong Y, He J, Wu K, Xie Y, Zhao W, Dai L, Liu L, Xiang R, Wei YQ, Zhang L, Peng Y. | 08/31/2019 |
| KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation. | KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Zhao H, Wang X, Yi P, Si Y, Tan P, He J, Yu S, Ren Y, Ma Y, Zhang J, Wang D, Wang F, Yu J., Free PMC Article | 09/22/2018 |
| The authors find that KHSRP associates with the regulatory domain of RIG-I to maintain the receptor in an inactive state and attenuate its sensing of viral RNA (vRNA). | Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation.
Soonthornvacharin S, Rodriguez-Frandsen A, Zhou Y, Galvez F, Huffmaster NJ, Tripathi S, Balasubramaniam VR, Inoue A, de Castro E, Moulton H, Stein DA, Sánchez-Aparicio MT, De Jesus PD, Nguyen Q, König R, Krogan NJ, García-Sastre A, Yoh SM, Chanda SK., Free PMC Article | 06/2/2018 |
| we discovered a novel mechanism underlying SUMOylation of KHSRP regulating the production of some special miRNAs. | SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis.
Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B, Yu J., Free PMC Article | 05/26/2018 |
| KSRP decreased EGR3 mRNA stability in an ARE-independent manner. | KSRP suppresses cell invasion and metastasis through miR-23a-mediated EGR3 mRNA degradation in non-small cell lung cancer.
Chien MH, Lee WJ, Yang YC, Li YL, Chen BR, Cheng TY, Yang PW, Wang MY, Jan YH, Lin YK, Lee JM, Hsiao M, Chen JS, Hua KT. | 12/23/2017 |
| TGF-beta-induced KHSRP silencing is central in a pathway leading to gene-expression. | miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition.
Puppo M, Bucci G, Rossi M, Giovarelli M, Bordo D, Moshiri A, Gorlero F, Gherzi R, Briata P. | 11/25/2017 |
| mechanistic evidence that KSRP promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation. | K-homology splicing regulatory protein (KSRP) promotes post-transcriptional destabilization of Spry4 transcripts in non-small cell lung cancer.
Bikkavilli RK, Zerayesus SA, Van Scoyk M, Wilson L, Wu PY, Baskaran A, Tang K, Raheem S, Samuelson BA, Reddy NM, Reddy SP, Cool CD, Kosmider B, Avasarala S, Winn RA., Free PMC Article | 06/10/2017 |
| The interaction between the KLHL12 and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells. | Control of the negative IRES trans-acting factor KHSRP by ubiquitination.
Kung YA, Hung CT, Chien KY, Shih SR., Free PMC Article | 06/10/2017 |
| The miRNA biogenesis factors, DDX17 and KHSRP, regulate the protein level of Ago2 in human cells. | The miRNA biogenesis factors, p72/DDX17 and KHSRP regulate the protein level of Ago2 in human cells.
Connerty P, Bajan S, Remenyi J, Fuller-Pace FV, Hutvagner G. | 06/3/2017 |
| Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis. | Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma.
Pruksakorn D, Teeyakasem P, Klangjorhor J, Chaiyawat P, Settakorn J, Diskul-Na-Ayudthaya P, Chokchaichamnankit D, Pothacharoen P, Srisomsap C., Free PMC Article | 04/8/2017 |
| High FBP2 expression is associated with doxorubicin resistance in breast cancer . | The far-upstream element-binding protein 2 is correlated with proliferation and doxorubicin resistance in human breast cancer cell lines.
Wang YY, Gu XL, Wang C, Wang H, Ni QC, Zhang CH, Yu XF, Yang LY, He ZX, Mao GX, Yang SY. | 03/4/2017 |
| Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells | KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer.
Tong L, Luo Y, Wei T, Guo L, Wang H, Zhu W, Zhang J. | 02/18/2017 |
| The expression of KSRP in liver epithelial cells controlled by mir-27b. | Upregulation of KSRP by miR-27b provides IFN-γ-induced post-transcriptional regulation of CX3CL1 in liver epithelial cells.
Xia Z, Lu Y, Li X, Mao T, Chen XM, Zhou R., Free PMC Article | 12/17/2016 |
| Khsrp as a highly regulated RBP in response to genotoxic stress. | Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression.
Boucas J, Fritz C, Schmitt A, Riabinska A, Thelen L, Peifer M, Leeser U, Nuernberg P, Altmueller J, Gaestel M, Dieterich C, Reinhardt HC., Free PMC Article | 02/13/2016 |
| Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication. | Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.
Chai F, Li HY, Wang W, Zhu XJ, Li Y, Wang S, Guo L, Zhang LK, Xiao G. | 08/22/2015 |
| The ability of KSRP to integrate different levels of gene expression is required for proper immune response. [Review] | KSRP controls pleiotropic cellular functions.
Gherzi R, Chen CY, Ramos A, Briata P. | 05/30/2015 |