| UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53. | UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
Huang Y, Zhu Y, Zhang Z, Li Z, Kong C. | 12/25/2021 |
| Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression. | Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Partscht P, Uddin B, Schiebel E. | 08/7/2021 |
| The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet beta-TC3 cells upon glucose stimulation. | The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.
Hu H, Yin JH, Shao DD, -L Wang L, He F, Huang XX, Guo HL, Xiang XN, Zhu SS, Zhang PH, Chen JS. | 05/15/2021 |
| When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS). | When transcripts matter: delineating between non-syndromic hearing loss DFNB32 and hearing impairment infertile male syndrome (HIIMS).
Mohseni M, Akbari M, Booth KT, Babanejad M, Azaiez H, Ardalani F, Arzhangi S, Jalalvand K, Nikzat N, Ghodratpour F, Jamali P, Adeli OA, Habibi H, Kahrizi K, Najmabadi H., Free PMC Article | 02/2/2021 |
| The study functionally characterizes two variants and provides further confirmatory evidence that CDC14A is associated with a rare form of hereditary hearing loss. | Novel Loss-of-Function Variants in CDC14A are Associated with Recessive Sensorineural Hearing Loss in Iranian and Pakistani Patients.
Doll J, Kolb S, Schnapp L, Rad A, Rüschendorf F, Khan I, Adli A, Hasanzadeh A, Liedtke D, Knaup S, Hofrichter MA, Müller T, Dittrich M, Kong IK, Kim HG, Haaf T, Vona B., Free PMC Article | 07/4/2020 |
| Point to differences in Cdk1-mediated mechanisms of regulation between human and yeast Cdc14 orthologues. | Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1.
Ovejero S, Ayala P, Malumbres M, Pimentel-Muiños FX, Bueno A, Sacristán MP., Free PMC Article | 10/19/2019 |
| we show that drebrin and hCDC14A regulate the recruitment of the actin organizer Arp2 to centrosomes. In addition, during ciliogenesis hCDC14A also regulates endocytosis and targeting of myosin Va vesicles to the basal body in a drebrin-independent manner, indicating that it impacts primary cilia formation in a multilayered manner. | The human phosphatase CDC14A modulates primary cilium length by regulating centrosomal actin nucleation.
Uddin B, Partscht P, Chen NP, Neuner A, Weiß M, Hardt R, Jafarpour A, Heßling B, Ruppert T, Lorenz H, Pereira G, Schiebel E., Free PMC Article | 08/17/2019 |
| CDC14A activity is necessary for hearing and male fertility. | CDC14A phosphatase is essential for hearing and male fertility in mouse and human.
Imtiaz A, Belyantseva IA, Beirl AJ, Fenollar-Ferrer C, Bashir R, Bukhari I, Bouzid A, Shaukat U, Azaiez H, Booth KT, Kahrizi K, Najmabadi H, Maqsood A, Wilson EA, Fitzgerald TS, Tlili A, Olszewski R, Lund M, Chaudhry T, Rehman AU, Starost MF, Waryah AM, Hoa M, Dong L, Morell RJ, Smith RJH, Riazuddin S, Masmoudi S, Kindt KS, Naz S, Friedman TB., Free PMC Article | 01/5/2019 |
| Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. Authors therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy. | Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm.
Chen NP, Uddin B, Hardt R, Ding W, Panic M, Lucibello I, Kammerer P, Ruppert T, Schiebel E., Free PMC Article | 05/5/2018 |
| Mutations in CDC14A gene are associated with Autosomal-Recessive Severe to Profound Deafness. | Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.
Delmaghani S, Aghaie A, Bouyacoub Y, El Hachmi H, Bonnet C, Riahi Z, Chardenoux S, Perfettini I, Hardelin JP, Houmeida A, Herbomel P, Petit C., Free PMC Article | 05/13/2017 |
| Overexpressed miR-301a may increase CDC14A expression and promote cell proliferation and migration in osteosarcomacells. Therefore, miR- 301a may be useful for osteosarcoma diagnosis and therapy. | Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A.
Ni Z, Shang XF, Wang YF, Sun YJ, Fu DJ. | 02/18/2017 |
| hCDC14A is down-regulated in many tumor tissues and reduced hCDC14A expression is correlated with poorer survival of patients with cancer | Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion.
Chen NP, Uddin B, Voit R, Schiebel E., Free PMC Article | 06/28/2016 |
| These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. | Zipper-interacting protein kinase interacts with human cell division cycle 14A phosphatase.
Wu W, Hu H, Ye Z, Leong M, He M, Li Q, Hu R, Zhang S. | 09/26/2015 |
| hCdc14A might be involved in cell cycle regulation in cultured human brain vascular endothelial cells during high glucose-, free fatty acids-, and hypoxia-induced injury. | HCdc14A is involved in cell cycle regulation of human brain vascular endothelial cells following injury induced by high glucose, free fatty acids and hypoxia.
Su J, Zhou H, Tao Y, Guo Z, Zhang S, Zhang Y, Huang Y, Tang Y, Hu R, Dong Q. | 08/15/2015 |
| These data support the hypothesis that Cdc14A counteracts Cdk1-cyclin B1 activity through Wee1 dephosphorylation. | Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation.
Ovejero S, Ayala P, Bueno A, Sacristán MP., Free PMC Article | 05/25/2013 |
| CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B. | Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
Ji M, Yang S, Chen Y, Xiao L, Zhang L, Dong J. | 11/17/2012 |
| Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes. | Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G₂/M transition.
Sacristán MP, Ovejero S, Bueno A. | 07/9/2011 |
| Cdc14A phosphatase prevents premature activation of Cdk1 regulating Cdc25A and Cdc25B at the entry into mitosis. | Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B.
Vázquez-Novelle MD, Mailand N, Ovejero S, Bueno A, Sacristán MP., Free PMC Article | 01/29/2011 |
| human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. | Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.
Mocciaro A, Berdougo E, Zeng K, Black E, Vagnarelli P, Earnshaw W, Gillespie D, Jallepalli P, Schiebel E., Free PMC Article | 07/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCentrosome-related genes, genetic variation, and risk of breast cancer.
Olson JE, Wang X, Pankratz VS, Fredericksen ZS, Vachon CM, Vierkant RA, Cerhan JR, Couch FJ. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
Song SY, Kang MR, Yoo NJ, Lee SH. | 06/30/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The authors found that Brap2, which has intrinsic RING domain dependent E3 ligase activity, facilitates HsCdc14A Lys-63 linked ubiquitin modification, indicating that Brap2 may be the ubiquitin E3 Ligase of HsCdc14A. | Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification.
Chen JS, Hu HY, Zhang S, He M, Hu RM. | 01/21/2010 |
| Cdc14A forms a stable complex with atypical mitogen-activated protein kinase Erk3 in human cells independent of its intrinsic phosphatase activity but mediated by its regulatory C-terminal domain. | A functional link between the human cell cycle-regulatory phosphatase Cdc14A and the atypical mitogen-activated kinase Erk3.
Hansen CA, Bartek J, Jensen S. | 01/21/2010 |
| PLK1-HsCdc14A interaction provides a temporal regulation of HsCdc14A in chromosome segregation during mitosis. | Phospho-regulation of HsCdc14A By Polo-like kinase 1 is essential for mitotic progression.
Yuan K, Hu H, Guo Z, Fu G, Shaw AP, Hu R, Yao X. | 01/21/2010 |
| Data suggest that hCdc14A phosphatase plays a role in the regulation of the centrosome cycle, mitosis, and cytokinesis, thereby influencing chromosome partitioning and genomic stability in human cells. | Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase.
Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK., Free PMC Article | 01/21/2010 |