| TRIM5alpha: A Protean Architect of Viral Recognition and Innate Immunity. | TRIM5α: A Protean Architect of Viral Recognition and Innate Immunity.
Spada SJ, Grigg ME, Bouamr F, Best SM, Zhang P., Free PMC Article | 08/13/2024 |
| TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery. | TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery.
Saha B, Olsvik H, Williams GL, Oh S, Evjen G, Sjøttem E, Mandell MA., Free PMC Article | 07/25/2024 |
| The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population. | The effect of TRIM5 variants on the susceptibility to HIV-1 infection and disease progression in the Polish population.
Bratosiewicz-Wąsik J, Miklasińska-Majdanik M, Wąsik TJ. | 02/15/2024 |
| TRIM5alpha restricts poxviruses and is antagonized by CypA and the viral protein C6. | TRIM5α restricts poxviruses and is antagonized by CypA and the viral protein C6.
Zhao Y, Lu Y, Richardson S, Sreekumar M, Albarnaz JD, Smith GL., Free PMC Article | 08/27/2023 |
| A frequent SNP in TRIM5alpha strongly enhances the innate immune response against LINE-1 elements. | A frequent SNP in TRIM5α strongly enhances the innate immune response against LINE-1 elements.
Lagisquet J, Conrad M, Wittmann S, Volkmann B, Weissinger H, Sticht H, Gramberg T., Free PMC Article | 05/23/2023 |
| The retroviral restriction factor TRIM5/TRIM5alpha regulates mitochondrial quality control. | The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control.
Saha B, Mandell MA., Free PMC Article | 01/11/2023 |
| Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5alpha in mitophagy. | Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagy.
Saha B, Salemi M, Williams GL, Oh S, Paffett ML, Phinney B, Mandell MA., Free PMC Article | 06/11/2022 |
| TRIM5alpha Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection. | TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection.
Selyutina A, Simons LM, Kirby KA, Bulnes-Ramos A, Hu P, Sarafianos SG, Hultquist JF, Diaz-Griffero F., Free PMC Article | 03/19/2022 |
| Knockdown of TRIM5alpha or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells. | Knockdown of TRIM5α or TRIM11 increases lentiviral vector transduction efficiency of human Muller cells.
Sauter MM, Brandt CR., Free PMC Article | 08/28/2021 |
| Human TRIM5alpha: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning. | Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning.
Cloherty APM, Rader AG, Compeer B, Ribeiro CMS., Free PMC Article | 08/14/2021 |
| Variations in Trim5alpha and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study. | Variations in Trim5α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study.
Amanya SB, Nyiro B, Waswa F, Obura B, Nakaziba R, Nabulime E, Katabazi AF, Nabatanzi R, Bayiyana A, Mboowa G, Kayongo A, Wayengera M, Sande OJ., Free PMC Article | 06/26/2021 |
| [Cellular and antiviral functions of TRIM5alpha].", trans "Fonctions cellulaires et antivirales de TRIM5alpha. | [Cellular and antiviral functions of TRIM5α].
Khalfi S, Mérindol N, Berthoux L. | 05/8/2021 |
| Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5alpha Binding to the Viral Core. | Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F., Free PMC Article | 03/27/2021 |
| Mutational resilience of antiviral restriction favors primate TRIM5alpha in host-virus evolutionary arms races. | Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.
Tenthorey JL, Young C, Sodeinde A, Emerman M, Malik HS., Free PMC Article | 03/6/2021 |
| Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5alpha can form hexagonal lattices or autophagy aggregates in vivo. | Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo.
Carter SD, Mamede JI, Hope TJ, Jensen GJ., Free PMC Article | 01/16/2021 |
| [Retrovirus Restriction Factor TRIM5alpha: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection]. | [Retrovirus Restriction Factor TRIM5α: The Mechanism of Action and Prospects for Use in Gene Therapy of HIV Infection].
Glazkova DV, Urusov FA, Bogoslovskaya EV, Shipulin GA. | 01/2/2021 |
| [Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients]. | [Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients].
Chen Y, Li Q, Zhang J, Gu R, Li K, Zhao G, Yuan H, Feng T, Ou D, Lin P., Free PMC Article | 10/24/2020 |
| Type-I-IFN-Stimulated Gene TRIM5gamma Inhibits HBV Replication by Promoting HBx Degradation. | Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation.
Tan G, Yi Z, Song H, Xu F, Li F, Aliyari R, Zhang H, Du P, Ding Y, Niu J, Wang X, Su L, Qin FX, Cheng G., Free PMC Article | 09/26/2020 |
| TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. | TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner.
Ohainle M, Kim K, Komurlu Keceli S, Felton A, Campbell E, Luban J, Emerman M., Free PMC Article | 08/13/2020 |
| TRIM5alpha suppresses replication of specific flaviviruses. TRIM5alpha binds to the viral protease to promote its proteasomal degradation. | TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Chiramel AI, Meyerson NR, McNally KL, Broeckel RM, Montoya VR, Méndez-Solís O, Robertson SJ, Sturdevant GL, Lubick KJ, Nair V, Youseff BH, Ireland RM, Bosio CM, Kim K, Luban J, Hirsch VM, Taylor RT, Bouamr F, Sawyer SL, Best SM., Free PMC Article | 08/12/2020 |
| Variations in the capsid protein result in alteration in the binding to the restriction factor huTRIM5alpha. | Interaction of human immunodeficiency virus-1 and human immunodeficiency virus-2 capsid amino acid variants with human tripartite motif 5α protein SPRY domain and its association with pathogenesis.
Ramalingam VV, Subramanian S, Fletcher GJ, Rupali P, Varghese G, Pulimood S, Jeyaseelan L, Nandagopal B, Sridharan G, Kannangai R. | 08/1/2020 |
| disruption of the capsid protein-CypA interaction renders HIV-1 susceptible to potent restriction by human TRIM5alpha, with the block occurring before reverse transcription | Cyclophilin A protects HIV-1 from restriction by human TRIM5α.
Kim K, Dauphin A, Komurlu S, McCauley SM, Yurkovetskiy L, Carbone C, Diehl WE, Strambio-De-Castillia C, Campbell EM, Luban J., Free PMC Article | 07/11/2020 |
| apply cryo-electron tomography and subtomogram averaging to determine structures of TRIM5alpha bound to recombinant HIV-1 capsid assemblies. Our data support a mechanism of hierarchical assembly, in which a limited number of basal interaction modes are successively organized in increasingly higher-order structures that culminate in a TRIM5alpha cage surrounding a retroviral capsid. | Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids.
Skorupka KA, Roganowicz MD, Christensen DE, Wan Y, Pornillos O, Ganser-Pornillos BK., Free PMC Article | 05/23/2020 |
| Human TRIM5alpha G249D mutant, associated with higher susceptibility to HIV-1 infection, formed fewer assemblies than WT protein, in agreement with homology modeling predictions and molecular dynamics simulations of dimers and higher oligomers of TRIM5alpha, providing a mechanistic explanation of the reduced antiviral activity of the G249D polymorphism. | Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α.
Kömürlü S, Bradley M, Smolin N, Imam S, Pauszek RF 3rd, Robia SL, Millar D, Nakayama EE, Shioda T, Campbell EM., Free PMC Article | 12/14/2019 |
| these data suggest that the specific hexagonal geometry of the TRIM5 lattice serves not only to enable virus binding but also to coordinate immune signaling with pathogen recognition. | Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling.
Fletcher AJ, Vaysburd M, Maslen S, Zeng J, Skehel JM, Towers GJ, James LC., Free PMC Article | 07/13/2019 |